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Selenoprotein P, plasma, 1
Symbols SEPP1 ; SELP; SeP
External IDs OMIM601484 MGI894288 HomoloGene3945 GeneCards: SEPP1 Gene
Species Human Mouse
Entrez 6414 20363
Ensembl ENSG00000250722 ENSMUSG00000064373
UniProt P49908 P70274
RefSeq (mRNA) NM_001085486 NM_001042613
RefSeq (protein) NP_001078955 NP_001036078
Location (UCSC) Chr 5:
42.8 – 42.89 Mb
Chr 15:
3.27 – 3.28 Mb
PubMed search [1] [2]

Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.[1][2]

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 9 Sec residues (human, rat, mouse - see Burk and Hill 2009) per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.[2]


Further reading[edit]

  • Burk RF, Hill KE (1994). "Selenoprotein P. A selenium-rich extracellular glycoprotein". J. Nutr. 124 (10): 1891–7. PMID 7931697. 
  • Mostert V (2000). "Selenoprotein P: properties, functions, and regulation". Arch. Biochem. Biophys. 376 (2): 433–8. doi:10.1006/abbi.2000.1735. PMID 10775431. 
  • Hill KE, Lloyd RS, Yang JG et al. (1991). "The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame". J. Biol. Chem. 266 (16): 10050–3. PMID 2037562. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Akesson B, Bellew T, Burk RF (1994). "Purification of selenoprotein P from human plasma". Biochim. Biophys. Acta 1204 (2): 243–9. doi:10.1016/0167-4838(94)90014-0. PMID 8142465. 
  • Hill KE, Dasouki M, Phillips JA, Burk RF (1997). "Human selenoprotein P gene maps to 5q31". Genomics 36 (3): 550–1. doi:10.1006/geno.1996.0505. PMID 8884283. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Mostert V, Lombeck I, Abel J (1998). "A novel method for the purification of selenoprotein P from human plasma". Arch. Biochem. Biophys. 357 (2): 326–30. doi:10.1006/abbi.1998.0809. PMID 9735174. 
  • Saito Y, Hayashi T, Tanaka A et al. (1999). "Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p". J. Biol. Chem. 274 (5): 2866–71. doi:10.1074/jbc.274.5.2866. PMID 9915822. 
  • Koyama H, Omura K, Ejima A et al. (1999). "Separation of selenium-containing proteins in human and mouse plasma using tandem high-performance liquid chromatography columns coupled with inductively coupled plasma-mass spectrometry". Anal. Biochem. 267 (1): 84–91. doi:10.1006/abio.1998.2949. PMID 9918658. 
  • Arteel GE, Franken S, Kappler J, Sies H (2000). "Binding of selenoprotein P to heparin: characterization with surface plasmon resonance". Biol. Chem. 381 (3): 265–8. doi:10.1515/BC.2000.034. PMID 10782998. 
  • Hondal RJ, Ma S, Caprioli RM et al. (2001). "Heparin-binding histidine and lysine residues of rat selenoprotein P". J. Biol. Chem. 276 (19): 15823–31. doi:10.1074/jbc.M010405200. PMID 11278668. 
  • Nishimura K, Matsumiya K, Tsujimura A et al. (2001). "Association of selenoprotein P with testosterone production in cultured Leydig cells". Arch. Androl. 47 (1): 67–76. doi:10.1080/01485010152104026. PMID 11442337. 
  • Al-Taie OH, Seufert J, Mörk H et al. (2003). "A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency". Eur. J. Hum. Genet. 10 (9): 499–504. doi:10.1038/sj.ejhg.5200811. PMID 12173025. 
  • Saito Y, Takahashi K (2003). "Characterization of selenoprotein P as a selenium supply protein". Eur. J. Biochem. 269 (22): 5746–51. doi:10.1046/j.1432-1033.2002.03298.x. PMID 12423375. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.