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Methionine sulfoxide reductase B1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols MSRB1 ; SELR; SELX; SEPX1; SepR
External IDs OMIM606216 MGI1351642 HomoloGene8455 GeneCards: MSRB1 Gene
EC number 1.8.4.-
Species Human Mouse
Entrez 51734 27361
Ensembl ENSG00000198736 ENSMUSG00000075705
UniProt Q9NZV6 Q9JLC3
RefSeq (mRNA) NM_016332 NM_013759
RefSeq (protein) NP_057416 NP_038787
Location (UCSC) Chr 16:
1.99 – 1.99 Mb
Chr 17:
24.74 – 24.74 Mb
PubMed search [1] [2]

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.[1][2]

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.[2]

See also[edit]


  1. ^ Lescure A, Gautheret D, Carbon P, Krol A (Feb 2000). "Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif". J Biol Chem 274 (53): 38147–54. doi:10.1074/jbc.274.53.38147. PMID 10608886. 
  2. ^ a b "Entrez Gene: SEPX1 selenoprotein X, 1". 

Further reading[edit]