SER-601

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SER-601
SER-601 structure.png
Systematic (IUPAC) name
N-(adamant-1-yl)-1-pentyl-4-oxo-6-isopropyl-1,4-dihydroquinoline-3-carboxamide
Clinical data
Legal status ?
Identifiers
CAS number 1048038-90-9 N
ATC code ?
PubChem CID 25034551
ChemSpider 24606023 YesY
ChEMBL CHEMBL502276 YesY
Chemical data
Formula C28H38N2O2 
Mol. mass 434.612 g/mol
 N (what is this?)  (verify)

SER-601 (COR-167) is a drug which acts as a potent and selective cannabinoid CB2 receptor agonist, based on a quinolone-3-carboxylic acid core structure, with 190x selectivity for CB2 over the related CB1 receptor. It has analgesic effects in animal studies, as well as neuroprotective effects,[1] but without cannabis-like behavioural effects due to its low affinity for CB1.[2] A number of related compounds are known, almost all of which have high selectivity for CB2.[3]

See also[edit]

References[edit]

  1. ^ Contartese, A.; Valoti, M.; Corelli, F.; Pasquini, S.; Mugnaini, C.; Pessina, F.; Aldinucci, C.; Sgaragli, G.; Frosini, M. (2012). "A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury". Pharmacological Research 66 (6): 555–563. doi:10.1016/j.phrs.2012.08.003. PMID 23036353.  edit
  2. ^ Pasquini S,et al. (August 2008). "Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo". Journal of Medicinal Chemistry 51 (16): 5075–84. doi:10.1021/jm800552f. PMID 18680276. 
  3. ^ Pasquini S,et al. (August 2010). "Investigations on the 4-quinolone-3-carboxylic acid motif. 3. Synthesis, structure-affinity relationships, and pharmacological characterization of 6-substituted 4-quinolone-3-carboxamides as highly selective cannabinoid-2 receptor ligands". Journal of Medicinal Chemistry 53 (16): 5915–28. doi:10.1021/jm100123x. PMID 20718492.