SERPINA6
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| Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 | |||||||||||
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 Crystal structure of corticosteroid-binding globulin. The reactive loop has been cleaved at the region highlighted in blue.[1] |
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| Identifiers | |||||||||||
| Symbols | SERPINA6; CBG | ||||||||||
| External IDs | OMIM: 122500 MGI: 88278 HomoloGene: 20417 GeneCards: SERPINA6 Gene | ||||||||||
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| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 866 | 12401 | |||||||||
| Ensembl | ENSG00000170099 | ENSMUSG00000060807 | |||||||||
| UniProt | P08185 | Q3UKW1 | |||||||||
| RefSeq (mRNA) | NM_001756 | NM_007618 | |||||||||
| RefSeq (protein) | NP_001747 | NP_031644 | |||||||||
| Location (UCSC) | Chr 14: 93.84 – 93.86 Mb |
Chr 12: 104.05 – 104.06 Mb |
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| PubMed search | [1] | [2] | |||||||||
Corticosteroid-binding globulin (CBG) also known as transcortin or serpin A6 is a protein that in humans is encoded by the SERPINA6 gene.[2][3][4]
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[edit] Function
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors (serpins) which may have evolved by duplication events.[4]
[edit] See also
- Serpin
- Circaseptan, 7-day biological cycle
[edit] References
- ^ PDB 2VDX; Zhou A, Wei Z, Stanley PL, Read RJ, Stein PE, Carrell RW (June 2008). "The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release". J. Mol. Biol. 380 (1): 244–51. doi:10.1016/j.jmb.2008.05.012. PMID 18513745.
- ^ Hammond GL, Smith CL, Goping IS, Underhill DA, Harley MJ, Reventos J, Musto NA, Gunsalus GL, Bardin CW (Aug 1987). "Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors". Proc Natl Acad Sci U S A 84 (15): 5153–7. doi:10.1073/pnas.84.15.5153. PMC 298812. PMID 3299377. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=298812.
- ^ Byth BC, Billingsley GD, Cox DW (Jul 1994). "Physical and genetic mapping of the serpin gene cluster at 14q32.1: allelic association and a unique haplotype associated with alpha 1-antitrypsin deficiency". Am J Hum Genet 55 (1): 126–33. PMC 1918218. PMID 7912884. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1918218.
- ^ a b "Entrez Gene: SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=866.
[edit] Further reading
- Rosner W, Beers PC, Awan T, Khan MS (1976). "Identification of corticosteroid-binding globulin in human milk: measurement with a filter disk assay.". J. Clin. Endocrinol. Metab. 42 (6): 1064–73. doi:10.1210/jcem-42-6-1064. PMID 932172.
- Smith CL, Power SG, Hammond GL (1992). "A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol.". J. Steroid Biochem. Mol. Biol. 42 (7): 671–6. doi:10.1016/0960-0760(92)90107-T. PMID 1504007.
- Brotherton J (1990). "Cortisol and transcortin in human seminal plasma and amniotic fluid as estimated by modern specific assays.". Andrologia 22 (3): 197–204. doi:10.1111/j.1439-0272.1990.tb01966.x. PMID 2240617.
- Seralini GE, Bérubé D, Gagné R, Hammond GL (1991). "The human corticosteroid binding globulin gene is located on chromosome 14q31-q32.1 near two other serine protease inhibitor genes.". Hum. Genet. 86 (1): 73–5. PMID 2253941.
- Underhill DA, Hammond GL (1990). "Organization of the human corticosteroid binding globulin gene and analysis of its 5'-flanking region.". Mol. Endocrinol. 3 (9): 1448–54. doi:10.1210/mend-3-9-1448. PMID 2608068.
- Loric S, Egloff M, Domingo M, et al. (1990). "Immunochemical characterization of corticosteroid-binding globulin in human bronchoalveolar fluid.". Clin. Chim. Acta 186 (1): 19–23. doi:10.1016/0009-8981(89)90198-8. PMID 2612005.
- Heubner A, Belovsky O, Müller W, et al. (1987). "Application of liquid-liquid partition chromatography in the simultaneous purification of sex-hormone-binding globulin and corticosteroid-binding globulin.". J. Chromatogr. 397: 419–34. doi:10.1016/S0021-9673(01)85027-5. PMID 2821037.
- Kato EA, Hsu BR, Kuhn RW (1988). "Comparative structural analyses of corticosteroid binding globulin.". J. Steroid Biochem. 29 (2): 213–20. doi:10.1016/0022-4731(88)90268-3. PMID 3347061.
- Bardin CW, Gunsalus GL, Musto NA, et al. (1988). "Corticosteroid binding globulin, testosterone-estradiol binding globulin, and androgen binding protein belong to protein families distinct from steroid receptors.". J. Steroid Biochem. 30 (1-6): 131–9. doi:10.1016/0022-4731(88)90085-4. PMID 3386241.
- Hammond GL, Langley MS (1986). "Identification and measurement of sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) in human saliva.". Acta Endocrinol. 112 (4): 603–8. PMID 3751467.
- Agrimonti F, Frairia R, Fornaro D, et al. (1983). "Circadian and circaseptan rhythmicities in corticosteroid-binding globulin (CBG) binding activity of human milk.". Chronobiologia 9 (3): 281–90. PMID 7172869.
- Misao R, Hori M, Ichigo S, et al. (1995). "Levels of sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) messenger ribonucleic acid (mRNAs) in ovarian endometriosis.". Reprod. Nutr. Dev. 35 (2): 155–65. doi:10.1051/rnd:19950204. PMID 7734053.
- Misao R, Hori M, Ichigo S, et al. (1995). "Corticosteroid-binding globulin mRNA levels in human uterine endometrium.". Steroids 59 (10): 603–7. doi:10.1016/0039-128X(94)90055-8. PMID 7878688.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Avvakumov GV, Hammond GL (1994). "Glycosylation of human corticosteroid-binding globulin. Differential processing and significance of carbohydrate chains at individual sites.". Biochemistry 33 (19): 5759–65. doi:10.1021/bi00185a012. PMID 8180202.
- Van Baelen H, Power SG, Hammond GL (1993). "Decreased cortisol-binding affinity of transcortin Leuven is associated with an amino acid substitution at residue-93.". Steroids 58 (6): 275–7. doi:10.1016/0039-128X(93)90072-U. PMID 8212073.
- Misao R, Nakanishi Y, Fujimoto J, et al. (1996). "Expression of corticosteroid-binding globulin mRNA in human uterine endometrial cancers.". Steroids 60 (10): 720–4. doi:10.1016/0039-128X(95)00106-Z. PMID 8539782.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
[edit] External links
- The MEROPS online database for peptidases and their inhibitors: I04.954
- MeSH SERPINA6+protein,+human
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