SERPINA9

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Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
Identifiers
Symbols SERPINA9 ; GCET1; SERPINA11; SERPINA11b
External IDs MGI1919157 HomoloGene23633 GeneCards: SERPINA9 Gene
Orthologs
Species Human Mouse
Entrez 327657 71907
Ensembl ENSG00000170054 ENSMUSG00000058260
UniProt Q86WD7 Q9D7D2
RefSeq (mRNA) NM_001042518 NM_027997
RefSeq (protein) NP_001035983 NP_082273
Location (UCSC) Chr 14:
94.93 – 94.95 Mb
Chr 12:
103.99 – 104.01 Mb
PubMed search [1] [2]

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1.[1] Serpin A9 is a member of the serpin family of serine protease inhibitors.

Function[edit]

The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.[2][3][4]

References[edit]

  1. ^ "Entrez Gene: SERPINA9". 
  2. ^ Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin". Biochem. J. 405 (3): 489–94. doi:10.1042/BJ20070174. PMC 2267310. PMID 17447896. 
  3. ^ Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID 17898315. 
  4. ^ Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas". Am. J. Clin. Pathol. 130 (1): 117–26. doi:10.1309/9QKE68QU7B825A3U. PMID 18550480. 

Further reading[edit]

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