SERPINB1

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Serpin peptidase inhibitor, clade B (ovalbumin), member 1
1HLE.png
Crystal structure of the cleaved equine leukocyte inhibitor.[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SERPINB1 ; EI; ELANH2; LEI; M/NEI; MNEI; PI-2; PI2
External IDs OMIM130135 MGI1913472 HomoloGene69399 GeneCards: SERPINB1 Gene
RNA expression pattern
PBB GE SERPINB1 213572 s at tn.png
PBB GE SERPINB1 212268 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1992 66222
Ensembl ENSG00000021355 ENSMUSG00000044734
UniProt P30740 Q9D154
RefSeq (mRNA) NM_030666 NM_025429
RefSeq (protein) NP_109591 NP_079705
Location (UCSC) Chr 6:
2.83 – 2.84 Mb
Chr 13:
32.84 – 32.85 Mb
PubMed search [1] [2]

Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.[2][3][4]

MNEI (murine neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1.[4]

Function[edit]

SerpinB1 is a cytoplasmic serine protease inhibitor of polymorphonuclear neutrophils. Among other serine proteases, it specifically inhibits neutrophil elastase, PR3 and cathepsin G, all found in neutrophil granules, by a suicide inhibition mechanism. SerpinB1 was found to reduce tissue damage caused by the mentioned proteases during inflammation and has a role in neutrophil homeostasis in mice. In various infection models (e.g. pneumonia) correlation of SerpinB1 absence and lack of microbial clearance have been shown. Different knockout strains serve as model to investigate the role of SerpinB1 in vivo.[5][6][7]

See also[edit]

References[edit]

  1. ^ PDB 1HLE; Baumann U, Bode W, Huber R, Travis J, Potempa J (August 1992). "Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1.95 A resolution". J. Mol. Biol. 226 (4): 1207–18. doi:10.1016/0022-2836(92)91062-T. PMID 1518052. 
  2. ^ Remold-O'Donnell E, Chin J, Alberts M (Jul 1992). "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor". Proc Natl Acad Sci U S A 89 (12): 5635–9. doi:10.1073/pnas.89.12.5635. PMC 49347. PMID 1376927. 
  3. ^ "Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1". 
  4. ^ a b Benarafa C, Remold-O'Donnell E (August 2005). "The ovalbumin serpins revisited: perspective from the chicken genome of clade B serpin evolution in vertebrates". Proc. Natl. Acad. Sci. U.S.A. 102 (32): 11367–72. doi:10.1073/pnas.0502934102. PMC 1183561. PMID 16055559. 
  5. ^ Gong D, Farley K, White M, Hartshorn KL, Benarafa C, Remold-O'Donnell E (August 2011). "Critical role of serpinB1 in regulating inflammatory responses in pulmonary influenza infection". J. Infect. Dis. 204 (4): 592–600. doi:10.1093/infdis/jir352. PMID 21791661. 
  6. ^ Benarafa C, LeCuyer TE, Baumann M, Stolley JM, Cremona TP, Remold-O'Donnell E (July 2011). "SerpinB1 protects the mature neutrophil reserve in the bone marrow". J. Leukoc. Biol. 90 (1): 21–9. doi:10.1189/jlb.0810461. PMID 21248149. 
  7. ^ Benarafa C, Priebe GP, Remold-O'Donnell E (August 2007). "The neutrophil serine protease inhibitor serpinb1 preserves lung defense functions in Pseudomonas aeruginosa infection". J. Exp. Med. 204 (8): 1901–9. doi:10.1084/jem.20070494. PMC 2118684. PMID 17664292. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.