SERPINB3

Serpin peptidase inhibitor, clade B (ovalbumin), member 3
Identifiers
Symbols	SERPINB3; HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1; T4-A
External IDs	OMIM: 600517 MGI: 2683295 HomoloGene: 74584 GeneCards: SERPINB3 Gene
Gene Ontology Molecular function • serine-type endopeptidase inhibitor activity • protein binding • peptidase inhibitor activity Cellular component • extracellular region • cytoplasm Biological process • negative regulation of endopeptidase activity • regulation of proteolysis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6317	394252
Ensembl	ENSG00000057149	ENSMUSG00000058017
UniProt	P29508	n/a
RefSeq (mRNA)	NM_006919	NM_201376.1
RefSeq (protein)	NP_008850	NP_958764.1
Location (UCSC)	Chr 18: 61.32 – 61.33 Mb	Chr 1: 108.97 – 108.98 Mb
PubMed search	[1]	[2]

Serpin B3 is a protein that in humans is encoded by the SERPINB3 gene.

See also

• Serpin

Further reading

• Suminami Y, Kishi F, Sekiguchi K, Kato H (1992). "Squamous cell carcinoma antigen is a new member of the serine protease inhibitors.". Biochem. Biophys. Res. Commun. 181 (1): 51–8. doi:10.1016/S0006-291X(05)81380-4. PMID 1958219. 
• Mino-Miyagawa N, Kimura Y, Hamamoto K (1990). "Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus.". Cancer 66 (7): 1505–12. doi:10.1002/1097-0142(19901001)66:7<1505::AID-CNCR2820660712>3.0.CO;2-V. PMID 2208001. 
• Mino N, Iio A, Hamamoto K (1988). "Availability of tumor-antigen 4 as a marker of squamous cell carcinoma of the lung and other organs.". Cancer 62 (4): 730–4. doi:10.1002/1097-0142(19880815)62:4<730::AID-CNCR2820620415>3.0.CO;2-W. PMID 2840187. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Schick C, Pemberton PA, Shi GP, et al. (1998). "Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.". Biochemistry 37 (15): 5258–66. doi:10.1021/bi972521d. PMID 9548757. 
• Cataltepe S, Gornstein ER, Schick C, et al. (2000). "Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas.". J. Histochem. Cytochem. 48 (1): 113–22. PMID 10653592. 
• Uemura Y, Pak SC, Luke C, et al. (2000). "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.". Int. J. Cancer 89 (4): 368–77. doi:10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6. PMID 10956412. 
• Hamada K, Shinomiya H, Asano Y, et al. (2001). "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter.". Biochim. Biophys. Acta 1518 (1-2): 124–31. PMID 11267667. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Shimada H, Nabeya Y, Okazumi S, et al. (2003). "Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma.". Surgery 133 (5): 486–94. doi:10.1067/msy.2003.139. PMID 12773976. 
• Micke O, Bruns F, Schäfer U, et al. (2003). "The clinical value of squamous cell carcinoma antigen in patients irradiated for locally advanced cancer of the head and neck.". Anticancer Res. 23 (2A): 907–11. PMID 12820321. 
• Nawata S, Nakamura K, Hirakawa H, et al. (2004). "Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues.". Electrophoresis 24 (14): 2277–82. doi:10.1002/elps.200305501. PMID 12874860. 
• Masumoto K, Sakata Y, Arima K, et al. (2003). "Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1.". J. Biol. Chem. 278 (46): 45296–304. doi:10.1074/jbc.M307741200. PMID 12949073. 
• Moore PL, Ong S, Harrison TJ (2004). "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system.". J. Biol. Chem. 278 (47): 46709–17. doi:10.1074/jbc.M302842200. PMID 12975381. 
• Onishi A, Nakashiro K, Mihara M, et al. (2004). "Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer.". Oncol. Rep. 11 (1): 33–9. PMID 14654899. 
• Hirakawa H, Nawata S, Sueoka K, et al. (2004). "Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line.". Oncol. Rep. 11 (2): 415–9. PMID 14719077. 
• Pontisso P, Calabrese F, Benvegnù L, et al. (2004). "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.". Br. J. Cancer 90 (4): 833–7. doi:10.1038/sj.bjc.6601543. PMC 2410161. PMID 14970861. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2410161. 
• Ruvoletto MG, Tono N, Carollo D, et al. (2004). "Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus.". J. Gen. Virol. 85 (Pt 3): 621–4. doi:10.1099/vir.0.19130-0. PMID 14993646. 

Turato C, Ruvoletto MG, Biasiolo A, et al. Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease. Dig Liver Dis. 2009 Mar;41(3):212-6. Epub 2008 Jul 25

External links

• The MEROPS online database for peptidases and their inhibitors: I04.008
• MeSH SERPINB3+protein,+human