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Serpin peptidase inhibitor, clade I (neuroserpin), member 1
Protein SERPINI1 PDB 1jjo.png
PDB rendering based on 1jjo.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SERPINI1 ; PI12; neuroserpin
External IDs OMIM602445 MGI1194506 HomoloGene21045 GeneCards: SERPINI1 Gene
RNA expression pattern
PBB GE SERPINI1 205352 at tn.png
More reference expression data
Species Human Mouse
Entrez 5274 20713
Ensembl ENSG00000163536 ENSMUSG00000027834
UniProt Q99574 O35684
RefSeq (mRNA) NM_001122752 NM_009250
RefSeq (protein) NP_001116224 NP_033276
Location (UCSC) Chr 3:
167.45 – 167.54 Mb
Chr 3:
75.56 – 75.64 Mb
PubMed search [1] [2]

Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.[1]

It is associated with Familial encephalopathy with neuroserpin inclusion bodies.

Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM][1]


SERPINI1 has been shown to interact with Tissue plasminogen activator.[2]


  1. ^ a b "Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1". 
  2. ^ Parmar, Parmjeet K; Coates Leigh C; Pearson John F; Hill Rena M; Birch Nigel P (September 2002). "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells". J. Neurochem. (England) 82 (6): 1406–15. doi:10.1046/j.1471-4159.2002.01100.x. ISSN 0022-3042. PMID 12354288. 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I04.025