SERPINI2

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Serpin peptidase inhibitor, clade I (pancpin), member 2
Identifiers
Symbols SERPINI2 ; MEPI; PANCPIN; PI14; TSA2004
External IDs OMIM605587 MGI1915181 HomoloGene21248 GeneCards: SERPINI2 Gene
RNA expression pattern
PBB GE SERPINI2 207636 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5276 67931
Ensembl ENSG00000114204 ENSMUSG00000034139
UniProt O75830 Q9JK88
RefSeq (mRNA) NM_001012303 NM_026460
RefSeq (protein) NP_001012303 NP_080736
Location (UCSC) Chr 3:
167.16 – 167.2 Mb
Chr 3:
75.24 – 75.27 Mb
PubMed search [1] [2]

Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.[1][2]

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.[2]

References[edit]

  1. ^ Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y (Jul 1998). "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells". Genes Chromosomes Cancer 22 (3): 179–85. doi:10.1002/(SICI)1098-2264(199807)22:3<179::AID-GCC3>3.0.CO;2-T. PMID 9624529. 
  2. ^ a b "Entrez Gene: SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I04.026