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Serpin peptidase inhibitor, clade I (pancpin), member 2
External IDs OMIM605587 MGI1915181 HomoloGene21248 GeneCards: SERPINI2 Gene
RNA expression pattern
PBB GE SERPINI2 207636 at tn.png
More reference expression data
Species Human Mouse
Entrez 5276 67931
Ensembl ENSG00000114204 ENSMUSG00000034139
UniProt O75830 Q9JK88
RefSeq (mRNA) NM_001012303 NM_026460
RefSeq (protein) NP_001012303 NP_080736
Location (UCSC) Chr 3:
167.16 – 167.2 Mb
Chr 3:
75.24 – 75.27 Mb
PubMed search [1] [2]

Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.[1][2]

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.[2]


  1. ^ Ozaki K, Nagata M, Suzuki M, Fujiwara T, Miyoshi Y, Ishikawa O, Ohigashi H, Imaoka S, Takahashi E, Nakamura Y (Jul 1998). "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells". Genes Chromosomes Cancer 22 (3): 179–85. doi:10.1002/(SICI)1098-2264(199807)22:3<179::AID-GCC3>3.0.CO;2-T. PMID 9624529. 
  2. ^ a b "Entrez Gene: SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I04.026