SF1 (gene)

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Splicing factor 1
Protein SF1 PDB 1k1g.png
PDB rendering based on 1k1g.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SF1 ; BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162
External IDs OMIM601516 MGI1095403 HomoloGene138518 GeneCards: SF1 Gene
RNA expression pattern
PBB GE SF1 208313 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7536 22668
Ensembl ENSG00000168066 ENSMUSG00000024949
UniProt Q15637 Q64213
RefSeq (mRNA) NM_001178030 NM_001110791
RefSeq (protein) NP_001171501 NP_001104261
Location (UCSC) Chr 11:
64.53 – 64.55 Mb
Chr 19:
6.36 – 6.38 Mb
PubMed search [1] [2]

Splicing factor 1 also known as zinc finger protein 162 (ZFM162) is a protein that in humans is encoded by the SF1 gene.[1][2][3]

Splicing factor SF1 is involved in the ATP-dependent formation of the spliceosome complex.[4]


SF1 (gene) has been shown to interact with Ewing sarcoma breakpoint region 1,[5] U2AF2,[6][7][8] Testis determining factor,[9]and Transcription elongation regulator 1.[10]


  1. ^ Toda T, Iida A, Miwa T, Nakamura Y, Imai T (Jul 1994). "Isolation and characterization of a novel gene encoding nuclear protein at a locus (D11S636) tightly linked to multiple endocrine neoplasia type 1 (MEN1)". Hum Mol Genet 3 (3): 465–70. doi:10.1093/hmg/3.3.465. PMID 7912130. 
  2. ^ Kramer A, Quentin M, Mulhauser F (Jun 1998). "Diverse modes of alternative splicing of human splicing factor SF1 deduced from the exon-intron structure of the gene". Gene 211 (1): 29–37. doi:10.1016/S0378-1119(98)00058-4. PMID 9573336. 
  3. ^ "Entrez Gene: SF1 splicing factor 1". 
  4. ^ Rino J, Desterro JM, Pacheco TR, Gadella TW, Carmo-Fonseca M (May 2008). "Splicing factors SF1 and U2AF associate in extraspliceosomal complexes". Mol. Cell. Biol. 28 (9): 3045–57. doi:10.1128/MCB.02015-07. PMC 2293075. PMID 18285458. 
  5. ^ Zhang D, Paley AJ, Childs G (July 1998). "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription". J. Biol. Chem. 273 (29): 18086–91. doi:10.1074/jbc.273.29.18086. PMID 9660765. 
  6. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  7. ^ Berglund JA, Abovich N, Rosbash M (March 1998). "A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition". Genes Dev. 12 (6): 858–67. doi:10.1101/gad.12.6.858. PMC 316625. PMID 9512519. 
  8. ^ Abovich N, Rosbash M (May 1997). "Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals". Cell 89 (3): 403–12. doi:10.1016/S0092-8674(00)80221-4. PMID 9150140. 
  9. ^ Kashimada K, Koopman P (December 2010). "Sry: the master switch in mammalian sex determination". Development 137 (23): 3921–30. doi:10.1242/dev.048983. PMID 21062860. 
  10. ^ Goldstrohm AC, Albrecht TR, Suñé C, Bedford MT, Garcia-Blanco MA (November 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMC 99933. PMID 11604498. 

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