SF3A1

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Splicing factor 3a, subunit 1, 120kDa
Protein SF3A1 PDB 1we7.png
PDB rendering based on 1we7.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SF3A1 ; PRP21; PRPF21; SAP114; SF3A120
External IDs OMIM605595 MGI1914715 HomoloGene4294 GeneCards: SF3A1 Gene
RNA expression pattern
PBB GE SF3A1 201356 at tn.png
PBB GE SF3A1 201357 s at tn.png
PBB GE SF3A1 216457 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10291 67465
Ensembl ENSG00000099995 ENSMUSG00000002129
UniProt Q15459 Q8K4Z5
RefSeq (mRNA) NM_001005409 NM_026175
RefSeq (protein) NP_001005409 NP_080451
Location (UCSC) Chr 22:
30.73 – 30.75 Mb
Chr 11:
4.16 – 4.18 Mb
PubMed search [1] [2]

Splicing factor 3 subunit 1 is a protein that in humans is encoded by the SF3A1 gene.[1][2]

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.[2]

Interactions[edit]

SF3A1 has been shown to interact with SF3A3[3][4] and CDC5L.[5]

References[edit]

Further reading[edit]

External links[edit]