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Splicing factor proline/glutamine-rich
Symbols SFPQ ; POMP100; PSF
External IDs OMIM605199 MGI1918764 HomoloGene3714 GeneCards: SFPQ Gene
RNA expression pattern
PBB GE SFPQ 201586 s at tn.png
PBB GE SFPQ 201585 s at tn.png
PBB GE SFPQ 214016 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6421 71514
Ensembl ENSG00000116560 ENSMUSG00000028820
UniProt P23246 Q8VIJ6
RefSeq (mRNA) NM_005066 NM_023603
RefSeq (protein) NP_005057 NP_076092
Location (UCSC) Chr 1:
35.64 – 35.66 Mb
Chr 4:
127.02 – 127.04 Mb
PubMed search [1] [2]

Splicing factor, proline- and glutamine-rich is a protein that in humans is encoded by the SFPQ gene.[1][2]


SFPQ has been shown to interact with PTBP1,[1][3] NONO,[4] CDC5L[5] and Ubiquitin C.[6]


  1. ^ a b Patton JG, Porro EB, Galceran J, Tempst P, Nadal-Ginard B (April 1993). "Cloning and characterization of PSF, a novel pre-mRNA splicing factor". Genes Dev 7 (3): 393–406. doi:10.1101/gad.7.3.393. PMID 8449401. 
  2. ^ "Entrez Gene: SFPQ splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)". 
  3. ^ Meissner, M; Dechat T, Gerner C, Grimm R, Foisner R, Sauermann G (January 2000). "Differential nuclear localization and nuclear matrix association of the splicing factors PSF and PTB". J. Cell. Biochem. (UNITED STATES) 76 (4): 559–66. doi:10.1002/(SICI)1097-4644(20000315)76:4<559::AID-JCB4>3.0.CO;2-U. ISSN 0730-2312. PMID 10653975. 
  4. ^ Peng, Rui; Dye Billy T, Pérez Ismael, Barnard Daron C, Thompson Amanda B, Patton James G (October 2002). "PSF and p54nrb bind a conserved stem in U5 snRNA". RNA (United States) 8 (10): 1334–47. doi:10.1017/S1355838202022070. ISSN 1355-8382. PMC 1370341. PMID 12403470. 
  5. ^ Ajuh, P; Kuster B, Panov K, Zomerdijk J C, Mann M, Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. 
  6. ^ Stelzl, Ulrich; Worm Uwe, Lalowski Maciej, Haenig Christian, Brembeck Felix H, Goehler Heike, Stroedicke Martin, Zenkner Martina, Schoenherr Anke, Koeppen Susanne, Timm Jan, Mintzlaff Sascha, Abraham Claudia, Bock Nicole, Kietzmann Silvia, Goedde Astrid, Toksöz Engin, Droege Anja, Krobitsch Sylvia, Korn Bernhard, Birchmeier Walter, Lehrach Hans, Wanker Erich E (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell (United States) 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. ISSN 0092-8674. PMID 16169070. 

Further reading[edit]