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Secreted frizzled-related protein 4
Symbols SFRP4 ; FRP-4; FRPHE; sFRP-4
External IDs OMIM606570 MGI892010 HomoloGene2267 GeneCards: SFRP4 Gene
RNA expression pattern
PBB GE SFRP4 204051 s at tn.png
PBB GE SFRP4 204052 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6424 20379
Ensembl ENSG00000106483 ENSMUSG00000021319
UniProt Q6FHJ7 Q9Z1N6
RefSeq (mRNA) NM_003014 NM_016687
RefSeq (protein) NP_003005 NP_057896
Location (UCSC) Chr 7:
37.95 – 38.07 Mb
Chr 13:
19.62 – 19.63 Mb
PubMed search [1] [2]

Secreted frizzled-related protein 4 is a protein that in humans is encoded by the SFRP4 gene.[1][2]


Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.[2]

SFRP4 is a hub gene in a Type 2 Diabetes-associated gene coexpression module in human islets, and reduces glucose-induced insulin secretion through decreased β-cell exocytosis. Expression and release of SFRP4 from islets is enhanced by interleukin-1β. SFRP4 is elevated in serum several years before clinical diagnosis of Type 2 Diabetes. Individuals who have above-average levels of SFRP4 in the blood are five times more likely to develop diabetes in the next few years than those with below-average levels.[3]


  1. ^ Abu-Jawdeh G, Comella N, Tomita Y, Brown LF, Tognazzi K, Sokol SY, Kocher O (May 1999). "Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy". Lab Invest 79 (4): 439–47. PMID 10211996. 
  2. ^ a b "Entrez Gene: SFRP4 secreted frizzled-related protein 4". 
  3. ^ Mahdi T, Hänzelmann Sonja, Salehi A, Muhammed SJ, Reinbothe TM, Tang Y, Axelsson AS, Zhou Y, Jing X, Almgren P, Krus U, Taneera J, Blom AM, Lyssenko V, Esguerra JLS, Hansson O, Eliasson L, Derry J, Zhang E, Wollheim CB, Groop L, Renström E, Rosengren AH (November 2012). "Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes". Cell Metabolism 16 (5): 625–633. doi:10.1016/j.cmet.2012.10.009. 

Further reading[edit]