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Serine/arginine-rich splicing factor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SRSF2 ; PR264; SC-35; SC35; SFRS2; SFRS2A; SRp30b
External IDs OMIM600813 MGI98284 HomoloGene37721 GeneCards: SRSF2 Gene
RNA expression pattern
PBB GE SFRS2 214882 s at tn.png
PBB GE SFRS2 200753 x at tn.png
PBB GE SFRS2 200754 x at tn.png
More reference expression data
Species Human Mouse
Entrez 6427 20382
Ensembl ENSG00000161547 ENSMUSG00000034120
UniProt Q01130 Q62093
RefSeq (mRNA) NM_001195427 NM_011358
RefSeq (protein) NP_001182356 NP_035488
Location (UCSC) Chr 17:
74.73 – 74.73 Mb
Chr 11:
116.85 – 116.85 Mb
PubMed search [1] [2]

Splicing factor, arginine/serine-rich 2 is a protein that in humans is encoded by the SFRS2 gene.[1][2][3]


SFRS2 has been shown to interact with CDC5L[4] and ASF/SF2.[5]


  1. ^ Bermingham JR Jr, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, Khotz J, Manley JL, Rosenfeld MG (February 1996). "Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2)". Genomics 29 (1): 70–9. doi:10.1006/geno.1995.1216. PMID 8530103. 
  2. ^ Fu XD, Maniatis T (May 1992). "Isolation of a complementary DNA that encodes the mammalian splicing factor SC35". Science 256 (5056): 535–8. doi:10.1126/science.1373910. PMID 1373910. 
  3. ^ "Entrez Gene: SFRS2 splicing factor, arginine/serine-rich 2". 
  4. ^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529. 
  5. ^ Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. (UNITED STATES) 16 (10): 5400–8. ISSN 0270-7306. PMC 231539. PMID 8816452. 

Further reading[edit]