SGCG

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Sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
Identifiers
Symbols SGCG ; A4; DAGA4; DMDA; DMDA1; LGMD2C; MAM; SCARMD2; SCG3; TYPE
External IDs OMIM608896 MGI1346524 HomoloGene194 GeneCards: SGCG Gene
RNA expression pattern
PBB GE SGCG 207302 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6445 24053
Ensembl ENSG00000102683 ENSMUSG00000035296
UniProt Q13326 P82348
RefSeq (mRNA) NM_000231 NM_011892
RefSeq (protein) NP_000222 NP_036022
Location (UCSC) Chr 13:
23.76 – 23.9 Mb
Chr 14:
61.22 – 61.26 Mb
PubMed search [1] [2]

Gamma-sarcoglycan is a protein that in humans is encoded by the SGCG gene.[1][2]

Gamma-sarcoglycan is one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin, probably to provide a link between the membrane associated cytoskeleton and the extracellular matrix. Defects in the protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C).[2]

Interactions[edit]

SGCG has been shown to interact with FLNC.[3][4]

References[edit]

  1. ^ Piccolo F, Jeanpierre M, Leturcq F, Dode C, Azibi K, Toutain A, Merlini L, Jarre L, Navarro C, Krishnamoorthy R, Tome FM, Urtizberea JA, Beckmann JS, Campbell KP, Kaplan JC (March 1997). "A founder mutation in the gamma-sarcoglycan gene of gypsies possibly predating their migration out of India". Hum Mol Genet 5 (12): 2019–22. doi:10.1093/hmg/5.12.2019. PMID 8968757. 
  2. ^ a b "Entrez Gene: SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)". 
  3. ^ Guyon, Jeffrey R; Kudryashova Elena; Potts Alexandra; Dalkilic Isin; Brosius Melissa A; Thompson Terri G; Beckmann Jacques S; Kunkel Louis M; Spencer Melissa J (October 2003). "Calpain 3 cleaves filamin C and regulates its ability to interact with gamma- and delta-sarcoglycans". Muscle Nerve (United States) 28 (4): 472–83. doi:10.1002/mus.10465. ISSN 0148-639X. PMID 14506720. 
  4. ^ Thompson, T G; Chan Y M; Hack A A; Brosius M; Rajala M; Lidov H G; McNally E M; Watkins S; Kunkel L M (January 2000). "Filamin 2 (FLN2): A muscle-specific sarcoglycan interacting protein". J. Cell Biol. (UNITED STATES) 148 (1): 115–26. doi:10.1083/jcb.148.1.115. ISSN 0021-9525. PMC 3207142. PMID 10629222. 

Further reading[edit]

External links[edit]