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Serum/glucocorticoid regulated kinase family, member 3
Protein SGK3 PDB 1xte.png
PDB rendering based on 1xte.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SGK3 ; CISK; SGK2; SGKL
External IDs OMIM607591 MGI2182368 HomoloGene56582 IUPHAR: 1536 GeneCards: SGK3 Gene
EC number
RNA expression pattern
PBB GE SGK3 220038 at tn.png
More reference expression data
Species Human Mouse
Entrez 23678 170755
Ensembl ENSG00000104205 ENSMUSG00000025915
UniProt Q96BR1 Q9ERE3
RefSeq (mRNA) NM_001033578 NM_001037759
RefSeq (protein) NP_001028750 NP_001032848
Location (UCSC) Chr 8:
67.58 – 67.77 Mb
Chr 1:
9.8 – 9.9 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase Sgk3 is an enzyme that in humans is encoded by the SGK3 gene.[1][2][3]


This gene is a member of the Ser/Thr protein kinase family and encodes a phosphoprotein with a PX (phox homology) domain. The protein phosphorylates several target proteins and has a role in neutral amino acid transport and activation of potassium and chloride channels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

In melanocytic cells SGK3 gene expression may be regulated by MITF.[4]


SGK3 has been shown to interact with GSK3B.[5]


  1. ^ Dai F, Yu L, He H, Zhao Y, Yang J, Zhang X et al. (February 2000). "Cloning and mapping of a novel human serum/glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1". Genomics 62 (1): 95–7. doi:10.1006/geno.1999.5969. PMID 10585774. 
  2. ^ Kobayashi T, Deak M, Morrice N, Cohen P (January 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 Pt 1 (Pt 1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550. 
  3. ^ a b "Entrez Gene: SGK3 serum/glucocorticoid regulated kinase family, member 3". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  5. ^ Dai F, Yu L, He H, Chen Y, Yu J, Yang Y et al. (May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction". Biochem. Biophys. Res. Commun. 293 (4): 1191–6. doi:10.1016/S0006-291X(02)00349-2. PMID 12054501. 

Further reading[edit]