SGOL1

Shugoshin-like 1 (S. pombe)
Identifiers
Symbols	SGOL1; FLJ14230; NY-BR-85; SGO; Sgo1
External IDs	OMIM: 609168 MGI: 1919665 HomoloGene: 23642 GeneCards: SGOL1 Gene
Gene Ontology Molecular function • protein binding Cellular component • chromosome, centromeric region • kinetochore • kinetochore • condensed chromosome kinetochore • condensed chromosome, centromeric region • condensed nuclear chromosome, centromeric region • spindle pole • nucleus • chromosome • cytoplasm • centrosome • cytosol • cytoskeleton • mitotic cohesin complex Biological process • M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • chromosome segregation • attachment of spindle microtubules to kinetochore • centriole-centriole cohesion • meiotic chromosome segregation • cell division Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	151648	72415
Ensembl	ENSG00000129810	ENSMUSG00000023940
UniProt	Q5FBB7	Q9CXH7
RefSeq (mRNA)	NM_001012409.2	NM_028232.2
RefSeq (protein)	NP_001012409.1	NP_082508.1
Location (UCSC)	Chr 3: 20.2 – 20.23 Mb	Chr 17: 53.81 – 53.83 Mb
PubMed search	[1]	[2]

Shugoshin-like 1 is a protein that in humans is encoded by the SGOL1 gene.

Further reading

• Wang X, Dai W (2005). "Shugoshin, a guardian for sister chromatid segregation.". Exp. Cell Res. 310 (1): 1–9. doi:10.1016/j.yexcr.2005.07.018. PMID 16112668. 
• Fu G, Ding X, Yuan K, et al. (2007). "Phosphorylation of human Sgo1 by NEK2A is essential for chromosome congression in mitosis.". Cell Res. 17 (7): 608–18. doi:10.1038/cr.2007.55. PMID 17621308. 
• Pouwels J, Kukkonen AM, Lan W, et al. (2007). "Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1.". Cell Cycle 6 (13): 1579–85. doi:10.4161/cc.6.13.4442. PMID 17617734. 
• Fu G, Hua S, Ward T, et al. (2007). "D-box is required for the degradation of human Shugoshin and chromosome alignment.". Biochem. Biophys. Res. Commun. 357 (3): 672–8. doi:10.1016/j.bbrc.2007.03.204. PMID 17448445. 
• Yang Y, Wang X, Dai W (2006). "Human Sgo1 is an excellent target for induction of apoptosis of transformed cells.". Cell Cycle 5 (8): 896–901. PMID 16628005. 
• Tang Z, Shu H, Qi W, et al. (2006). "PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.". Dev. Cell 10 (5): 575–85. doi:10.1016/j.devcel.2006.03.010. PMID 16580887. 
• Kitajima TS, Sakuno T, Ishiguro K, et al. (2006). "Shugoshin collaborates with protein phosphatase 2A to protect cohesin.". Nature 441 (7089): 46–52. doi:10.1038/nature04663. PMID 16541025. 
• McGuinness BE, Hirota T, Kudo NR, et al. (2006). "Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells.". PLoS Biol. 3 (3): e86. doi:10.1371/journal.pbio.0030086. PMC 1054882. PMID 15737064. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1054882. 
• Kitajima TS, Hauf S, Ohsugi M, et al. (2005). "Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization.". Curr. Biol. 15 (4): 353–9. doi:10.1016/j.cub.2004.12.044. PMID 15723797. 
• Tang Z, Sun Y, Harley SE, et al. (2005). "Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis.". Proc. Natl. Acad. Sci. U.S.A. 101 (52): 18012–7. doi:10.1073/pnas.0408600102. PMC 539817. PMID 15604152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=539817. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.