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Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SGTA ; SGT; alphaSGT; hSGT
External IDs OMIM603419 MGI1098703 HomoloGene31122 GeneCards: SGTA Gene
RNA expression pattern
PBB GE SGTA 201396 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6449 52551
Ensembl ENSG00000104969 ENSMUSG00000004937
UniProt O43765 Q8BJU0
RefSeq (mRNA) NM_003021 NM_024499
RefSeq (protein) NP_003012 NP_078775
Location (UCSC) Chr 19:
2.75 – 2.78 Mb
Chr 10:
81.04 – 81.06 Mb
PubMed search [1] [2]

Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene.[1][2][3] SGTA orthologs [4] have also been identified in several mammals for which complete genome data are available.


This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.[3]


SGTA has been shown to interact with Growth hormone receptor.[2]


  1. ^ Kordes E, Savelyeva L, Schwab M, Rommelaere J, Jauniaux JC, Cziepluch C (Aug 1998). "Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans". Genomics 52 (1): 90–4. doi:10.1006/geno.1998.5385. PMID 9740675. 
  2. ^ a b Schantl JA, Roza M, De Jong AP, Strous GJ (Aug 2003). "Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor". The Biochemical Journal 373 (Pt 3): 855–63. doi:10.1042/BJ20021591. PMC 1223544. PMID 12735788. 
  3. ^ a b "Entrez Gene: SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha". 
  4. ^ "OrthoMaM phylogenetic marker: SGTA coding sequence". 

Further reading[edit]