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SH2B adaptor protein 2
Protein SH2B2 PDB 1q2h.png
PDB rendering based on 1q2h.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SH2B2 ; APS
External IDs OMIM605300 MGI1345171 HomoloGene10309 GeneCards: SH2B2 Gene
Species Human Mouse
Entrez 10603 23921
Ensembl ENSG00000160999 ENSMUSG00000005057
UniProt O14492 Q9JID9
RefSeq (mRNA) NM_020979 NM_018825
RefSeq (protein) NP_066189 NP_061295
Location (UCSC) Chr 7:
101.93 – 101.96 Mb
Chr 5:
136.22 – 136.24 Mb
PubMed search [1] [2]

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.[1][2]


The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.[2]


SH2B2 has been shown to interact with TrkA[3] and Cbl gene.[4][5]


  1. ^ Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A (Aug 1997). "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation". Oncogene 15 (1): 7–15. doi:10.1038/sj.onc.1201163. PMID 9233773. 
  2. ^ a b "Entrez Gene: SH2B2 SH2B adaptor protein 2". 
  3. ^ Qian X, Riccio A, Zhang Y, Ginty DD (Nov 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron 21 (5): 1017–29. doi:10.1016/S0896-6273(00)80620-0. PMID 9856458. 
  4. ^ Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S et al. (May 1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia 13 (5): 760–7. doi:10.1038/sj/leu/2401397. PMID 10374881. 
  5. ^ Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (Mar 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755. PMID 18273061. 

Further reading[edit]