From Wikipedia, the free encyclopedia
Jump to: navigation, search
SH2B adaptor protein 3
Symbols SH2B3 ; IDDM20; LNK
External IDs OMIM605093 MGI893598 HomoloGene36179 GeneCards: SH2B3 Gene
RNA expression pattern
PBB GE SH2B3 203320 at tn.png
More reference expression data
Species Human Mouse
Entrez 10019 16923
Ensembl ENSG00000111252 ENSMUSG00000042594
UniProt Q9UQQ2 O09039
RefSeq (mRNA) NM_001291424 NM_008507
RefSeq (protein) NP_001278353 NP_032533
Location (UCSC) Chr 12:
111.84 – 111.89 Mb
Chr 5:
121.82 – 121.84 Mb
PubMed search [1] [2]

SH2B adapter protein 3 is a protein that in humans is encoded by the SH2B3 gene.[1][2]


T-cell activation requires stimulation of the T-cell receptor (TCR; see MIM 186880)-CD3 (see CD3Z; MIM 186780) complex, followed by recruitment of an array of intracellular signaling proteins (e.g., GRB2 (MIM 108355) and PLCG1 (MIM 172420)). Mediating the interaction between the extracellular receptors and intracellular signaling pathways are adaptor proteins such as LAT (MIM 602354), TRIM (MIM 604962), and LNK.[supplied by OMIM][2]


SH2B3 has been shown to interact with Filamin.[3]


  1. ^ Li Y, He X, Schembri-King J, Jakes S, Hayashi J (June 2000). "Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation". J Immunol 164 (10): 5199–206. doi:10.4049/jimmunol.164.10.5199. PMID 10799879. 
  2. ^ a b "Entrez Gene: SH2B3 SH2B adaptor protein 3". 
  3. ^ He X, Li Y, Schembri-King J, Jakes S, Hayashi J (August 2000). "Identification of actin binding protein, ABP-280, as a binding partner of human Lnk adaptor protein". Mol. Immunol. 37 (10): 603–12. doi:10.1016/S0161-5890(00)00070-5. PMID 11163396. 

Further reading[edit]

External links[edit]