From Wikipedia, the free encyclopedia
Jump to: navigation, search
SH2 domain containing 1B
Symbols SH2D1B ; EAT2
External IDs OMIM608510 MGI1349420 HomoloGene8070 GeneCards: SH2D1B Gene
Species Human Mouse
Entrez 117157 26904
Ensembl ENSG00000198574 ENSMUSG00000096334
UniProt O14796 O35324
RefSeq (mRNA) NM_053282 NM_012009
RefSeq (protein) NP_444512 NP_036139
Location (UCSC) Chr 1:
162.37 – 162.38 Mb
Chr 1:
170.28 – 170.29 Mb
PubMed search [1] [2]

SH2 domain-containing protein 1B is a protein that in humans is encoded by the SH2D1B gene.[1][2][3]

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001).[supplied by OMIM][3]


SH2D1B has been shown to interact with SLAMF1.[2]


  1. ^ Thompson AD, Braun BS, Arvand A, Stewart SD, May WA, Chen E, Korenberg J, Denny C (Feb 1997). "EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene". Oncogene 13 (12): 2649–58. PMID 9000139. 
  2. ^ a b Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (Nov 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425. 
  3. ^ a b "Entrez Gene: SH2D1B SH2 domain containing 1B". 

Further reading[edit]