SH3GL2

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SH3-domain GRB2-like 2
Protein SH3GL2 PDB 1x03.png
PDB rendering based on 1x03.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SH3GL2 ; CNSA2; EEN-B1; SH3D2A; SH3P4
External IDs OMIM604465 MGI700009 HomoloGene20652 GeneCards: SH3GL2 Gene
RNA expression pattern
PBB GE SH3GL2 205751 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6456 20404
Ensembl ENSG00000107295 ENSMUSG00000028488
UniProt Q99962 Q62420
RefSeq (mRNA) NM_003026 NM_019535
RefSeq (protein) NP_003017 NP_062408
Location (UCSC) Chr 9:
17.58 – 17.8 Mb
Chr 4:
85.21 – 85.64 Mb
PubMed search [1] [2]

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.[1][2]


Interactions[edit]

SH3GL2 has been shown to interact with DNM1,[3][4] Amphiphysin,[3][4] ADAM9,[5] SH3KBP1[6] and ADAM15.[5]

References[edit]

  1. ^ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142. 
  2. ^ "Entrez Gene: SH3GL2 SH3-domain GRB2-like 2". 
  3. ^ a b Micheva, K D; Kay B K, McPherson P S (Oct 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. (UNITED STATES) 272 (43): 27239–45. doi:10.1074/jbc.272.43.27239. ISSN 0021-9258. PMID 9341169. 
  4. ^ a b Modregger, Jan; Schmidt Anne A, Ritter Brigitte, Huttner Wieland B, Plomann Markus (Feb 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. (United States) 278 (6): 4160–7. doi:10.1074/jbc.M208568200. ISSN 0021-9258. PMID 12456676. 
  5. ^ a b Howard, L; Nelson K K, Maciewicz R A, Blobel C P (Oct 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. (UNITED STATES) 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. ISSN 0021-9258. PMID 10531379. 
  6. ^ Soubeyran, Philippe; Kowanetz Katarzyna, Szymkiewicz Iwona, Langdon Wallace Y, Dikic Ivan (Mar 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature (England) 416 (6877): 183–7. doi:10.1038/416183a. ISSN 0028-0836. PMID 11894095. 

Further reading[edit]