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SH3-domain GRB2-like 2
Protein SH3GL2 PDB 1x03.png
PDB rendering based on 1x03.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SH3GL2 ; CNSA2; EEN-B1; SH3D2A; SH3P4
External IDs OMIM604465 MGI700009 HomoloGene20652 GeneCards: SH3GL2 Gene
RNA expression pattern
PBB GE SH3GL2 205751 at tn.png
More reference expression data
Species Human Mouse
Entrez 6456 20404
Ensembl ENSG00000107295 ENSMUSG00000028488
UniProt Q99962 Q62420
RefSeq (mRNA) NM_003026 NM_019535
RefSeq (protein) NP_003017 NP_062408
Location (UCSC) Chr 9:
17.58 – 17.8 Mb
Chr 4:
85.21 – 85.64 Mb
PubMed search [1] [2]

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.[1][2]


SH3GL2 has been shown to interact with DNM1,[3][4] Amphiphysin,[3][4] ADAM9,[5] SH3KBP1[6] and ADAM15.[5]


  1. ^ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142. 
  2. ^ "Entrez Gene: SH3GL2 SH3-domain GRB2-like 2". 
  3. ^ a b Micheva, K D; Kay B K; McPherson P S (Oct 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. (UNITED STATES) 272 (43): 27239–45. doi:10.1074/jbc.272.43.27239. ISSN 0021-9258. PMID 9341169. 
  4. ^ a b Modregger, Jan; Schmidt Anne A; Ritter Brigitte; Huttner Wieland B; Plomann Markus (Feb 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. (United States) 278 (6): 4160–7. doi:10.1074/jbc.M208568200. ISSN 0021-9258. PMID 12456676. 
  5. ^ a b Howard, L; Nelson K K; Maciewicz R A; Blobel C P (Oct 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. (UNITED STATES) 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. ISSN 0021-9258. PMID 10531379. 
  6. ^ Soubeyran, Philippe; Kowanetz Katarzyna; Szymkiewicz Iwona; Langdon Wallace Y; Dikic Ivan (Mar 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature (England) 416 (6877): 183–7. doi:10.1038/416183a. ISSN 0028-0836. PMID 11894095. 

Further reading[edit]