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SH3-domain GRB2-like 3
Protein SH3GL3 PDB 2ew3.png
PDB rendering based on 2ew3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SH3GL3 ; CNSA3; EEN-B2; HsT19371; SH3D2C; SH3P13
External IDs OMIM603362 MGI700011 HomoloGene37723 GeneCards: SH3GL3 Gene
RNA expression pattern
PBB GE SH3GL3 205637 s at tn.png
PBB GE SH3GL3 gnf1h02191 at tn.png
PBB GE SH3GL3 gnf1h02192 x at tn.png
More reference expression data
Species Human Mouse
Entrez 6457 20408
Ensembl ENSG00000140600 ENSMUSG00000030638
UniProt Q99963 Q62421
RefSeq (mRNA) NM_001301108 NM_001277954
RefSeq (protein) NP_001288037 NP_001264883
Location (UCSC) Chr 15:
84.12 – 84.29 Mb
Chr 7:
82.17 – 82.31 Mb
PubMed search [1] [2]

Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.[1][2]


SH3GL3 has been shown to interact with Huntingtin[3] and SH3KBP1.[4]


  1. ^ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (July 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142. 
  2. ^ "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3". 
  3. ^ Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H et al. (October 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. PMID 9809064. 
  4. ^ Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096. 

Further reading[edit]