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SH3-domain kinase binding protein 1
Protein SH3KBP1 PDB 1wi7.png
PDB rendering based on 1wi7.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SH3KBP1 ; CD2BP3; CIN85; GIG10; HSB-1; HSB1; MIG18
External IDs OMIM300374 MGI1889583 HomoloGene10971 GeneCards: SH3KBP1 Gene
Species Human Mouse
Entrez 30011 58194
Ensembl ENSG00000147010 ENSMUSG00000040990
UniProt Q96B97 Q8R550
RefSeq (mRNA) NM_001024666 NM_001135727
RefSeq (protein) NP_001019837 NP_001129199
Location (UCSC) Chr X:
19.55 – 19.91 Mb
Chr X:
159.63 – 159.98 Mb
PubMed search [1] [2]

SH3 domain-containing kinase-binding protein 1 is an enzyme that in humans is encoded by the SH3KBP1 gene.[1][2]

CBL (MIM 165360) constitutively interacts with SH3 domain-containing proteins and, upon tyrosine phosphorylation, with SH2 domain-containing proteins. The SH3KBP1 gene encodes an 85-kD CBL-interacting protein that enhances tumor necrosis factor (MIM 191160)-mediated apoptotic cell death (Narita et al., 2001).[supplied by OMIM][3]


SH3KBP1 has been shown to interact with B-cell linker,[4] Grb2,[5][6] SH3GLB2,[7][8] SH3GL3,[7] SH3GL2,[8] BCAR1,[4] Epidermal growth factor receptor,[8][9] CBLB,[9] Cbl gene,[4][6][7][8][9] SOS1,[4] CRK[4] and PAK2.[10]


  1. ^ Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (May 1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549. 
  2. ^ Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O, et al. (November 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098. 
  3. ^ "Entrez Gene: SH3KBP1 SH3-domain kinase binding protein 1". 
  4. ^ a b c d e Watanabe, S; Take H; Takeda K; Yu Z X; Iwata N; Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochem. Biophys. Res. Commun. (UNITED STATES) 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. ISSN 0006-291X. PMID 11071869. 
  5. ^ Gout, I; Middleton G; Adu J; Ninkina N N; Drobot L B; Filonenko V; Matsuka G; Davies A M; Waterfield M; Buchman V L (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". EMBO J. (ENGLAND) 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. ISSN 0261-4189. PMC 306608. PMID 10921882. 
  6. ^ a b Borinstein, S C; Hyatt M A; Sykes V W; Straub R E; Lipkowitz S; Boulter J; Bogler O (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cell. Signal. (ENGLAND) 12 (11–12): 769–79. doi:10.1016/S0898-6568(00)00129-7. ISSN 0898-6568. PMID 11152963. 
  7. ^ a b c Petrelli, Annalisa; Gilestro Giorgio F; Lanzardo Stefania; Comoglio Paolo M; Migone Nicola; Giordano Silvia (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature (England) 416 (6877): 187–90. doi:10.1038/416187a. ISSN 0028-0836. PMID 11894096. 
  8. ^ a b c d Soubeyran, Philippe; Kowanetz Katarzyna; Szymkiewicz Iwona; Langdon Wallace Y; Dikic Ivan (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature (England) 416 (6877): 183–7. doi:10.1038/416183a. ISSN 0028-0836. PMID 11894095. 
  9. ^ a b c Szymkiewicz, Iwona; Kowanetz Katarzyna; Soubeyran Philippe; Dinarina Ana; Lipkowitz Stanley; Dikic Ivan (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". J. Biol. Chem. (United States) 277 (42): 39666–72. doi:10.1074/jbc.M205535200. ISSN 0021-9258. PMID 12177062. 
  10. ^ Kurakin, Alexei V; Wu Susan; Bredesen Dale E (September 2003). "Atypical recognition consensus of CIN85/SETA/Ruk SH3 domains revealed by target-assisted iterative screening". J. Biol. Chem. (United States) 278 (36): 34102–9. doi:10.1074/jbc.M305264200. ISSN 0021-9258. PMID 12829691. 

Further reading[edit]