SH3RF1

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SH3 domain containing ring finger 1
Identifiers
Symbols SH3RF1 ; POSH; RNF142; SH3MD2
External IDs MGI1913066 HomoloGene10988 GeneCards: SH3RF1 Gene
RNA expression pattern
PBB GE SH3RF1 gnf1h05668 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 57630 59009
Ensembl ENSG00000154447 ENSMUSG00000031642
UniProt Q7Z6J0 Q69ZI1
RefSeq (mRNA) NM_020870 NM_021506
RefSeq (protein) NP_065921 NP_067481
Location (UCSC) Chr 4:
170.02 – 170.19 Mb
Chr 8:
61.22 – 61.4 Mb
PubMed search [1] [2]

Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene.[1][2]

Function[edit]

This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.[2]

Interactions[edit]

SH3RF1 has been shown to interact with AKT2[3] and MAP3K11.[3]

References[edit]

  1. ^ Tapon N, Nagata K, Lamarche N, Hall A (Apr 1998). "A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways". EMBO J. 17 (5): 1395–404. doi:10.1093/emboj/17.5.1395. PMC 1170487. PMID 9482736. 
  2. ^ a b "Entrez Gene: SH3RF1 SH3 domain containing ring finger 1". 
  3. ^ a b Figueroa C, Tarras S, Taylor J, Vojtek AB (Nov 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284. 

Further reading[edit]