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SH3 domain containing ring finger 1
Symbols SH3RF1 ; POSH; RNF142; SH3MD2
External IDs MGI1913066 HomoloGene10988 GeneCards: SH3RF1 Gene
RNA expression pattern
PBB GE SH3RF1 gnf1h05668 at tn.png
More reference expression data
Species Human Mouse
Entrez 57630 59009
Ensembl ENSG00000154447 ENSMUSG00000031642
UniProt Q7Z6J0 Q69ZI1
RefSeq (mRNA) NM_020870 NM_021506
RefSeq (protein) NP_065921 NP_067481
Location (UCSC) Chr 4:
170.02 – 170.19 Mb
Chr 8:
61.22 – 61.4 Mb
PubMed search [1] [2]

Putative E3 ubiquitin-protein ligase SH3RF1 is an enzyme that in humans is encoded by the SH3RF1 gene.[1][2]


This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as a ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.[2]


SH3RF1 has been shown to interact with AKT2[3] and MAP3K11.[3]


  1. ^ Tapon N, Nagata K, Lamarche N, Hall A (Apr 1998). "A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways". EMBO J. 17 (5): 1395–404. doi:10.1093/emboj/17.5.1395. PMC 1170487. PMID 9482736. 
  2. ^ a b "Entrez Gene: SH3RF1 SH3 domain containing ring finger 1". 
  3. ^ a b Figueroa C, Tarras S, Taylor J, Vojtek AB (Nov 2003). "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex". J. Biol. Chem. 278 (48): 47922–7. doi:10.1074/jbc.M307357200. PMID 14504284. 

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