SHB (gene)

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Src homology 2 domain containing adaptor protein B
Symbols SHB ; bA3J10.2
External IDs OMIM600314 MGI98294 HomoloGene74458 GeneCards: SHB Gene
RNA expression pattern
PBB GE SHB 204657 s at tn.png
PBB GE SHB 204656 at tn.png
More reference expression data
Species Human Mouse
Entrez 6461 230126
Ensembl ENSG00000107338 ENSMUSG00000044813
UniProt Q15464 Q6PD21
RefSeq (mRNA) NM_003028 NM_001033306
RefSeq (protein) NP_003019 NP_001028478
Location (UCSC) Chr 9:
37.92 – 38.07 Mb
Chr 4:
45.42 – 45.53 Mb
PubMed search [1] [2]

SH2 domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene.[1][2]


SHB (gene) has been shown to interact with Fibroblast growth factor receptor 1,[3] Src,[3] Linker of activated T cells,[4][5] Lymphocyte cytosolic protein 2,[5] ZAP-70,[5] EPS8,[3] PIK3R1[3] and VAV1.[5]


  1. ^ Yulug IG, Hillermann R, Fisher EM (May 1995). "The SHB adaptor protein maps to human chromosome 9". Genomics 24 (3): 615–7. doi:10.1006/geno.1994.1681. PMID 7713524. 
  2. ^ "Entrez Gene: SHB Src homology 2 domain containing adaptor protein B". 
  3. ^ a b c d Karlsson, T; Songyang Z, Landgren E, Lavergne C, Di Fiore P P, Anafi M, Pawson T, Cantley L C, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene (ENGLAND) 10 (8): 1475–83. ISSN 0950-9232. PMID 7537362. 
  4. ^ Lindholm, C K; Gylfe E; Zhang W; Samelson L E; Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". J. Biol. Chem. (UNITED STATES) 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. ISSN 0021-9258. PMID 10488157. 
  5. ^ a b c d Lindholm, Cecilia K; Henriksson Maria L; Hallberg Bengt; Welsh Michael (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T-1 cells". Eur. J. Biochem. (Germany) 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. ISSN 0014-2956. PMID 12084069. 

Further reading[edit]