SHC2
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| SHC (Src homology 2 domain containing) transforming protein 2 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SHC2; SCK; SHCB; SLI | ||||||||||||
| External IDs | OMIM: 605217 MGI: 106180 HomoloGene: 19127 GeneCards: SHC2 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 25759 | 216148 | |||||||||||
| Ensembl | ENSG00000129946 | ENSMUSG00000020312 | |||||||||||
| UniProt | P98077 | Q8BMC3 | |||||||||||
| RefSeq (mRNA) | XM_001129272 | NM_001024539.1 | |||||||||||
| RefSeq (protein) | XP_001129272 | NP_001019710.1 | |||||||||||
| Location (UCSC) | Chr 19: 0.42 – 0.46 Mb |
Chr 10: 79.08 – 79.1 Mb |
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| PubMed search | [1] | [2] | |||||||||||
SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.[1][2][3]
[edit] Interactions
SHC2 has been shown to interact with Kinase insert domain receptor.[4]
[edit] References
- ^ Kavanaugh WM, Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science 266 (5192): 1862–5. doi:10.1126/science.7527937. PMID 7527937.
- ^ Nakamura T, Muraoka S, Sanokawa R, Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002.
- ^ "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25759.
- ^ Warner, A J; Lopez-Dee J, Knight E L, Feramisco J R, Prigent S A (Apr. 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. (England) 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220983.
[edit] Further reading
- Choy KW, Wang CC, Ogura A, et al. (2007). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes.". Physiol. Genomics 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
- Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Liu HY, Meakin SO (2002). "ShcB and ShcC activation by the Trk family of receptor tyrosine kinases.". J. Biol. Chem. 277 (29): 26046–56. doi:10.1074/jbc.M111659200. PMID 12006576.
- Warner AJ, Lopez-Dee J, Knight EL, et al. (2001). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.". Biochem. J. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. PMC 1220983. PMID 10749680. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1220983.
- Pelicci G, Dente L, De Giuseppe A, et al. (1996). "A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.". Oncogene 13 (3): 633–41. PMID 8760305.
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