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SHC (Src homology 2 domain containing) transforming protein 2
Symbols SHC2 ; SCK; SHCB; SLI
External IDs OMIM605217 MGI106180 HomoloGene19127 ChEMBL: 3299 GeneCards: SHC2 Gene
RNA expression pattern
PBB GE SHC2 213464 at tn.png
More reference expression data
Species Human Mouse
Entrez 25759 216148
Ensembl ENSG00000129946 ENSMUSG00000020312
UniProt P98077 Q8BMC3
RefSeq (mRNA) NM_012435 NM_001024539
RefSeq (protein) NP_036567 NP_001019710
Location (UCSC) Chr 19:
0.42 – 0.46 Mb
Chr 10:
79.62 – 79.64 Mb
PubMed search [1] [2]

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.[1][2][3]


SHC2 has been shown to interact with Kinase insert domain receptor.[4]


  1. ^ Kavanaugh WM, Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science 266 (5192): 1862–5. doi:10.1126/science.7527937. PMID 7527937. 
  2. ^ Nakamura T, Muraoka S, Sanokawa R, Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002. 
  3. ^ "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2". 
  4. ^ Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (Apr 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. (England) 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680. 

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