SHC2

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SHC (Src homology 2 domain containing) transforming protein 2
Identifiers
Symbols SHC2 ; SCK; SHCB; SLI
External IDs OMIM605217 MGI106180 HomoloGene19127 ChEMBL: 3299 GeneCards: SHC2 Gene
RNA expression pattern
PBB GE SHC2 213464 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25759 216148
Ensembl ENSG00000129946 ENSMUSG00000020312
UniProt P98077 Q8BMC3
RefSeq (mRNA) NM_012435 NM_001024539
RefSeq (protein) NP_036567 NP_001019710
Location (UCSC) Chr 19:
0.42 – 0.46 Mb
Chr 10:
79.62 – 79.64 Mb
PubMed search [1] [2]

SHC-transforming protein 2 is a protein that in humans is encoded by the SHC2 gene.[1][2][3]


Interactions[edit]

SHC2 has been shown to interact with Kinase insert domain receptor.[4]

References[edit]

  1. ^ Kavanaugh WM, Williams LT (Jan 1995). "An alternative to SH2 domains for binding tyrosine-phosphorylated proteins". Science 266 (5192): 1862–5. doi:10.1126/science.7527937. PMID 7527937. 
  2. ^ Nakamura T, Muraoka S, Sanokawa R, Mori N (Apr 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J Biol Chem 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. PMID 9507002. 
  3. ^ "Entrez Gene: SHC2 SHC (Src homology 2 domain containing) transforming protein 2". 
  4. ^ Warner, A J; Lopez-Dee J, Knight E L, Feramisco J R, Prigent S A (Apr 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. (England) 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983. PMID 10749680. 

Further reading[edit]