SHC3

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SHC (Src homology 2 domain containing) transforming protein 3
Identifiers
Symbols SHC3 ; N-Shc; NSHC; RAI; SHCC
External IDs OMIM605263 MGI106179 HomoloGene7536 GeneCards: SHC3 Gene
RNA expression pattern
PBB GE SHC3 206330 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 53358 20418
Ensembl ENSG00000148082 ENSMUSG00000021448
UniProt Q92529 Q61120
RefSeq (mRNA) NM_016848 NM_009167
RefSeq (protein) NP_058544 NP_033193
Location (UCSC) Chr 9:
91.63 – 91.79 Mb
Chr 13:
51.43 – 51.57 Mb
PubMed search [1] [2]

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.[1][2]


Interactions[edit]

SHC3 has been shown to interact with RICS[3] and TrkB.[4][5]

References[edit]

  1. ^ Nakamura T, Sanokawa R, Sasaki Y, Ayusawa D, Oishi M, Mori N (November 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene 13 (6): 1111–21. PMID 8808684. 
  2. ^ "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3". 
  3. ^ Nakamura, Takeshi; Komiya Misako; Sone Kiyoaki; Hirose Eiji; Gotoh Noriko; Morii Hiroshi; Ohta Yasutaka; Mori Nozomu (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. (United States) 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. ISSN 0270-7306. PMC 139861. PMID 12446789. 
  4. ^ Nakamura, T; Muraoka S; Sanokawa R; Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. (UNITED STATES) 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. ISSN 0021-9258. PMID 9507002. 
  5. ^ Suzuki, Shingo; Mizutani Masaharu; Suzuki Kenji; Yamada Masashi; Kojima Masami; Hatanaka Hiroshi; Koizumi Shinichi (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochem. Biophys. Res. Commun. (United States) 294 (5): 1087–92. doi:10.1016/S0006-291X(02)00606-X. ISSN 0006-291X. PMID 12074588. 

Further reading[edit]