SIGIRR

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Identifiers
Symbols	SIGIRR; MGC110992; TIR8
External IDs	OMIM: 605478 MGI: 1344402 HomoloGene: 36399 GeneCards: SIGIRR Gene
Gene Ontology Molecular function • transmembrane receptor activity • protein binding Cellular component • membrane • integral to membrane Biological process • negative regulation of cytokine-mediated signaling pathway • acute-phase response • signal transduction • negative regulation of lipopolysaccharide-mediated signaling pathway • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of chemokine biosynthetic process • innate immune response Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59307	24058
Ensembl	ENSG00000185187	ENSMUSG00000025494
UniProt	Q6IA17	Q3UKS3
RefSeq (mRNA)	NM_001135053.1	NM_023059.3
RefSeq (protein)	NP_001128525.1	NP_075546.2
Location (UCSC)	Chr 11: 0.41 – 0.42 Mb	Chr 7: 148.28 – 148.29 Mb
PubMed search	[1]	[2]

Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene.

Interactions

SIGIRR has been shown to interact with TRAF6.

Further reading

• Du X, Poltorak A, Wei Y, Beutler B (2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution.". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Wald D, Qin J, Zhao Z, et al. (2003). "SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling.". Nat. Immunol. 4 (9): 920–7. doi:10.1038/ni968. PMID 12925853. 
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Polentarutti N, Rol GP, Muzio M, et al. (2004). "Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR.". Eur. Cytokine Netw. 14 (4): 211–8. PMID 14715412. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Qin J, Qian Y, Yao J, et al. (2005). "SIGIRR inhibits interleukin-1 receptor- and toll-like receptor 4-mediated signaling through different mechanisms.". J. Biol. Chem. 280 (26): 25233–41. doi:10.1074/jbc.M501363200. PMID 15866876.