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SIN3 transcription regulator family member B
Protein SIN3B PDB 1e91.png
PDB rendering based on 1e91.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SIN3B ; KIAA0700
External IDs OMIM607777 MGI107158 HomoloGene81810 GeneCards: SIN3B Gene
RNA expression pattern
PBB GE SIN3B 209352 s at tn.png
PBB GE SIN3B 39705 at tn.png
More reference expression data
Species Human Mouse
Entrez 23309 20467
Ensembl ENSG00000127511 ENSMUSG00000031622
UniProt O75182 Q62141
RefSeq (mRNA) NM_001297595 NM_001113248
RefSeq (protein) NP_001284524 NP_001106719
Location (UCSC) Chr 19:
16.94 – 16.99 Mb
Chr 8:
72.72 – 72.76 Mb
PubMed search [1] [2]

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.[1][2]


SIN3B has been shown to interact with HDAC1,[3][4] Zinc finger and BTB domain-containing protein 16,[5] SUDS3[6] and IKZF1.[4][7]

See also[edit]


  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (December 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. 
  2. ^ "Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)". 
  3. ^ Zhang, Y; Ng H H; Erdjument-Bromage H; Tempst P; Bird A; Reinberg D (August 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev. (UNITED STATES) 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. ISSN 0890-9369. PMC 316920. PMID 10444591. 
  4. ^ a b Koipally, J; Renold A; Kim J; Georgopoulos K (June 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". EMBO J. (ENGLAND) 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. ISSN 0261-4189. PMC 1171390. PMID 10357820. 
  5. ^ David, G; Alland L; Hong S H; Wong C W; DePinho R A; Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene (ENGLAND) 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. ISSN 0950-9232. PMID 9627120. 
  6. ^ Alland, Leila; David Gregory, Shen-Li Hong, Potes Jason, Muhle Rebecca, Lee Hye-Chun, Hou Harry, Chen Ken, DePinho Ronald A (April 2002). "Identification of Mammalian Sds3 as an Integral Component of the Sin3/Histone Deacetylase Corepressor Complex". Mol. Cell. Biol. (United States) 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. ISSN 0270-7306. PMC 133736. PMID 11909966. 
  7. ^ Koipally, Joseph; Georgopoulos Katia (August 2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. (United States) 277 (31): 27697–705. doi:10.1074/jbc.M201694200. ISSN 0021-9258. PMID 12015313. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.