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Sirtuin 5
Protein SIRT5 PDB 2b4y.png
PDB rendering based on 2b4y.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SIRT5 ; SIR2L5
External IDs OMIM604483 MGI1915596 HomoloGene40825 IUPHAR: 2711 GeneCards: SIRT5 Gene
RNA expression pattern
PBB GE SIRT5 219185 at tn.png
PBB GE SIRT5 221010 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23408 68346
Ensembl ENSG00000124523 ENSMUSG00000054021
UniProt Q9NXA8 Q8K2C6
RefSeq (mRNA) NM_001193267 NM_178848
RefSeq (protein) NP_001180196 NP_849179
Location (UCSC) Chr 6:
13.57 – 13.61 Mb
Chr 13:
43.37 – 43.4 Mb
PubMed search [1] [2]

Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5 gene and in other species by the Sirt5 gene.[1]

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in two transcript variants.[1]


Further reading[edit]