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Src kinase associated phosphoprotein 2
Protein SKAP2 PDB 1u5e.png
PDB rendering based on 1u5e.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM605215 MGI1889206 HomoloGene2919 GeneCards: SKAP2 Gene
RNA expression pattern
PBB GE SKAP2 204362 at tn.png
PBB GE SKAP2 204361 s at tn.png
PBB GE SKAP2 216899 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8935 54353
Ensembl ENSG00000005020 ENSMUSG00000059182
UniProt O75563 Q3UND0
RefSeq (mRNA) NM_003930 NM_018773
RefSeq (protein) NP_003921 NP_061243
Location (UCSC) Chr 7:
26.71 – 27.03 Mb
Chr 6:
51.86 – 52.01 Mb
PubMed search [1] [2]

Src kinase-associated phosphoprotein 2 is an enzyme that in humans is encoded by the SKAP2 gene.[1][2][3]

The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated phosphoprotein 1. It is an adaptor protein that is thought to play an essential role in the src signaling pathway in various cells. It inhibits PTK2B/RAFTK activity and regulates alpha-synuclein phosphorylation.[3]


  1. ^ Kouroku Y, Soyama A, Fujita E, Urase K, Tsukahara T, Momoi T (Jan 1999). "RA70 is a src kinase-associated protein expressed ubiquitously". Biochem Biophys Res Commun 252 (3): 738–42. doi:10.1006/bbrc.1998.9637. PMID 9837776. 
  2. ^ Marie-Cardine A, Verhagen AM, Eckerskorn C, Schraven B (Oct 1998). "SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55". FEBS Lett 435 (1): 55–60. doi:10.1016/S0014-5793(98)01040-0. PMID 9755858. 
  3. ^ a b "Entrez Gene: SKAP2 src kinase associated phosphoprotein 2". 

Further reading[edit]