SkBr3 is a cell line isolated by the Memorial Sloan–Kettering Cancer Center in 1970. It was derived from a pleural effusion due to an adenocarcinoma originating in the breast of a 43 year old, caucasian female. The cell line over-expresses the HER2 gene product. 
The SkBr3 line is synonymous(derived from the same patient) with the AU565 cell line.
- "ATCC Product Description". Retrieved 26 February 2012.
- "LBL Breast Cancer Cell Collection: Cell Line AU565". Retrieved 26 February 2012.
- "Overcoming Trastuzumab Resistance in HER2-Overexpressing Breast Cancer Cells by Using a Novel Celecoxib-Derived Phosphoinositide-Dependent Kinase-1 Inhibitor". Retrieved 26 February 2012.