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SKI-like proto-oncogene
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SKIL ; SNO; SnoA; SnoI; SnoN
External IDs OMIM165340 MGI106203 HomoloGene3948 GeneCards: SKIL Gene
RNA expression pattern
PBB GE SKIL 206675 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6498 20482
Ensembl ENSG00000136603 ENSMUSG00000027660
UniProt P12757 Q60665
RefSeq (mRNA) NM_001145097 NM_001039090
RefSeq (protein) NP_001138569 NP_001034179
Location (UCSC) Chr 3:
170.08 – 170.11 Mb
Chr 3:
31.1 – 31.12 Mb
PubMed search [1] [2]

Ski-like protein is a protein that in humans is encoded by the SKIL gene.[1][2]


SKIL has been shown to interact with SKI protein,[3] Mothers against decapentaplegic homolog 3[4][5] and Mothers against decapentaplegic homolog 2.[4][5]


  1. ^ Nomura N, Sasamoto S, Ishii S, Date T, Matsui M, Ishizaki R (September 1989). "Isolation of human cDNA clones of ski and the ski-related gene, sno". Nucleic Acids Res 17 (14): 5489–500. doi:10.1093/nar/17.14.5489. PMC 318172. PMID 2762147. 
  2. ^ "Entrez Gene: SKIL SKI-like oncogene". 
  3. ^ Cohen, S B; Zheng G; Heyman H C; Stavnezer E (February 1999). "Heterodimers of the SnoN and Ski oncoproteins form preferentially over homodimers and are more potent transforming agents". Nucleic Acids Res. (ENGLAND) 27 (4): 1006–14. doi:10.1093/nar/27.4.1006. ISSN 0305-1048. PMC 148280. PMID 9927733. 
  4. ^ a b Stroschein, S L; Bonni S; Wrana J L; Luo K (November 2001). "Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN". Genes Dev. (United States) 15 (21): 2822–36. doi:10.1101/gad.912901. ISSN 0890-9369. PMC 312804. PMID 11691834. 
  5. ^ a b Stroschein, S L; Wang W; Zhou S; Zhou Q; Luo K (October 1999). "Negative feedback regulation of TGF-beta signaling by the SnoN oncoprotein". Science (UNITED STATES) 286 (5440): 771–4. doi:10.1126/science.286.5440.771. ISSN 0036-8075. PMID 10531062. 

Further reading[edit]