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This article is about a human gene. For the kanji indexing system, see Kodansha Kanji Learner's Dictionary. For the non-profit organizations, see SKIP of New York.
Inositol polyphosphate-5-phosphatase K
Symbols INPP5K ; PPS; SKIP
External IDs OMIM607875 MGI1194899 HomoloGene75059 GeneCards: INPP5K Gene
EC number
RNA expression pattern
PBB GE SKIP 202781 s at tn.png
PBB GE SKIP 202782 s at tn.png
More reference expression data
Species Human Mouse
Entrez 51763 19062
Ensembl ENSG00000132376 ENSMUSG00000006127
UniProt Q9BT40 Q8C5L6
RefSeq (mRNA) NM_001135642 NM_008916
RefSeq (protein) NP_001129114 NP_032942
Location (UCSC) Chr 17:
1.4 – 1.42 Mb
Chr 11:
75.63 – 75.65 Mb
PubMed search [1] [2]

SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.[1]

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[1] Overexpression of SKIP in mice affects osmoregulation in kidney collecting ducts.[2]


  1. ^ a b "Entrez Gene: SKIP skeletal muscle and kidney enriched inositol phosphatase". 
  2. ^ Pernot, E; Terryn S, Cheong SC, Markadieu N, Janas S, Blockmans M, Jacoby M, Pouillon V, Gayral S, Rossier BC, Beauwens R, Erneux C, Devuyst O, Schurmans S. (2011). "The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system.". Pflugers Arch. 462 (6): 871–83. doi:10.1007/s00424-011-1028-0. PMID 21938401. 

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