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Src-like-adaptor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SLA2 ; C20orf156; MARS; SLAP-2; SLAP2
External IDs OMIM606577 HomoloGene49989 GeneCards: SLA2 Gene
Species Human Mouse
Entrez 84174 77799
Ensembl ENSG00000101082 ENSMUSG00000027636
UniProt Q9H6Q3 Q8R4L0
RefSeq (mRNA) NM_032214 NM_029983
RefSeq (protein) NP_115590 NP_084259
Location (UCSC) Chr 20:
35.24 – 35.27 Mb
Chr 2:
156.87 – 156.89 Mb
PubMed search [1] [2]

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.[1][2]

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.[2]


SLA2 has been shown to interact with Cbl gene.[3]


  1. ^ Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P, Spencer C, Fu A, Sheng N, Yu P, Pali E, Nagin A, Shen M, Yu S, Chan E, Wu X, Li C, Woisetschlager M, Aversa G, Kolbinger F, Bennett MK, Molineaux S, Luo Y, Payan DG, Mancebo HS, Wu J (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med 194 (9): 1263–76. doi:10.1084/jem.194.9.1263. PMC 2195979. PMID 11696592. 
  2. ^ a b "Entrez Gene: SLA2 Src-like-adaptor 2". 
  3. ^ Pandey, Akhilesh; Ibarrola Nieves, Kratchmarova Irina, Fernandez Minerva M, Constantinescu Stefan N, Ohara Osamu, Sawasdikosol Sansana, Lodish Harvey F, Mann Matthias (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. (United States) 277 (21): 19131–8. doi:10.1074/jbc.M110318200. ISSN 0021-9258. PMID 11891219. 

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