SLA2

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Src-like-adaptor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols SLA2 ; C20orf156; MARS; SLAP-2; SLAP2
External IDs OMIM606577 HomoloGene49989 GeneCards: SLA2 Gene
Orthologs
Species Human Mouse
Entrez 84174 77799
Ensembl ENSG00000101082 ENSMUSG00000027636
UniProt Q9H6Q3 Q8R4L0
RefSeq (mRNA) NM_032214 NM_029983
RefSeq (protein) NP_115590 NP_084259
Location (UCSC) Chr 20:
35.24 – 35.27 Mb
Chr 2:
156.87 – 156.89 Mb
PubMed search [1] [2]

Src-like-adapter 2 is a protein that in humans is encoded by the SLA2 gene.[1][2]

Function[edit]

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.[2]

Interactions[edit]

SLA2 has been shown to interact with Cbl gene.[3]

References[edit]

  1. ^ Holland SJ, Liao XC, Mendenhall MK, Zhou X, Pardo J, Chu P et al. (Nov 2001). "Functional cloning of Src-like adapter protein-2 (SLAP-2), a novel inhibitor of antigen receptor signaling". J Exp Med 194 (9): 1263–76. doi:10.1084/jem.194.9.1263. PMC 2195979. PMID 11696592. 
  2. ^ a b "Entrez Gene: SLA2 Src-like-adaptor 2". 
  3. ^ Pandey A, Ibarrola N, Kratchmarova I, Fernandez MM, Constantinescu SN, Ohara O et al. (May 2002). "A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling". J. Biol. Chem. 277 (21): 19131–8. doi:10.1074/jbc.M110318200. PMID 11891219. 

Further reading[edit]