SLAMF1
From Wikipedia, the free encyclopedia
| Signaling lymphocytic activation molecule family member 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Rendering of SLAMF1 from PDB 1D4T |
|||||||||||||
|
|||||||||||||
| Identifiers | |||||||||||||
| Symbols | SLAMF1; CD150; CDw150; SLAM | ||||||||||||
| External IDs | OMIM: 603492 MGI: 1351314 HomoloGene: 48162 GeneCards: SLAMF1 Gene | ||||||||||||
|
|||||||||||||
| RNA expression pattern | |||||||||||||
 |
|||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 6504 | 27218 | |||||||||||
| Ensembl | ENSG00000117090 | ENSMUSG00000015316 | |||||||||||
| UniProt | Q13291 | Q18PK4 | |||||||||||
| RefSeq (mRNA) | NM_003037 | NM_013730.4 | |||||||||||
| RefSeq (protein) | NP_003028 | NP_038758.2 | |||||||||||
| Location (UCSC) | Chr 1: 160.58 – 160.62 Mb |
Chr 1: 173.7 – 173.73 Mb |
|||||||||||
| PubMed search | [1] | [2] | |||||||||||
Signaling lymphocytic activation molecule is a protein that in humans is encoded by the SLAMF1 gene.[1][2]
SLAMF1 has also recently has been designated CD150 (cluster of differentiation 150).
[edit] Interactions
SLAMF1 has been shown to interact with PTPN11,[3][4] SH2D1A[3][5] and SH2D1B.[4]
[edit] References
- ^ Cocks BG, Chang CC, Carballido JM, Yssel H, de Vries JE, Aversa G (Aug 1995). "A novel receptor involved in T-cell activation". Nature 376 (6537): 260–3. doi:10.1038/376260a0. PMID 7617038.
- ^ "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6504.
- ^ a b Howie, Duncan; Simarro María, Sayos Joan, Guirado Maria, Sancho Jaime, Terhorst Cox (Feb. 2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation". Blood (United States) 99 (3): 957–65. doi:10.1182/blood.V99.3.957. ISSN 0006-4971. PMID 11806999.
- ^ a b Morra, M; Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle A J, Denny C, Yaffe M B, Engel P, Eck M J, Terhorst C (Nov. 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. (England) 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. ISSN 0261-4189. PMC 125701. PMID 11689425. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125701.
- ^ Morra, M; Simarro-Grande M, Martin M, Chen A S, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck M J, Sumegi J, Engel P, Li S C, Terhorst C (Sep. 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. (United States) 276 (39): 36809–16. doi:10.1074/jbc.M101305200. ISSN 0021-9258. PMID 11477068.
[edit] Further reading
- Punnonen J, Cocks BG, Carballido JM, et al. (1997). "Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes.". J. Exp. Med. 185 (6): 993–1004. doi:10.1084/jem.185.6.993. PMC 2196230. PMID 9091591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196230.
- Sayos J, Wu C, Morra M, et al. (1998). "The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM.". Nature 395 (6701): 462–9. doi:10.1038/26683. PMID 9774102.
- Mikhalap SV, Shlapatska LM, Berdova AG, et al. (1999). "CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis.". J. Immunol. 162 (10): 5719–27. PMID 10229804.
- Li SC, Gish G, Yang D, et al. (2000). "Novel mode of ligand binding by the SH2 domain of the human XLP disease gene product SAP/SH2D1A.". Curr. Biol. 9 (23): 1355–62. doi:10.1016/S0960-9822(00)80080-9. PMID 10607564.
- Rogge L, Bianchi E, Biffi M, et al. (2000). "Transcript imaging of the development of human T helper cells using oligonucleotide arrays.". Nat. Genet. 25 (1): 96–101. doi:10.1038/75671. PMID 10802665.
- Tatsuo H, Ono N, Tanaka K, Yanagi Y (2000). "SLAM (CDw150) is a cellular receptor for measles virus.". Nature 406 (6798): 893–7. doi:10.1038/35022579. PMID 10972291.
- Lewis J, Eiben LJ, Nelson DL, et al. (2001). "Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.". Clin. Immunol. 100 (1): 15–23. doi:10.1006/clim.2001.5035. PMID 11414741.
- Morra M, Simarro-Grande M, Martin M, et al. (2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients.". J. Biol. Chem. 276 (39): 36809–16. doi:10.1074/jbc.M101305200. PMID 11477068.
- Kruse M, Meinl E, Henning G, et al. (2001). "Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta.". J. Immunol. 167 (4): 1989–95. PMID 11489980.
- Bleharski JR, Niazi KR, Sieling PA, et al. (2001). "Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines.". J. Immunol. 167 (6): 3174–81. PMID 11544303.
- Morra M, Lu J, Poy F, et al. (2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125701.
- Howie D, Simarro M, Sayos J, et al. (2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation.". Blood 99 (3): 957–65. doi:10.1182/blood.V99.3.957. PMID 11806999.
- Murabayashi N, Kurita-Taniguchi M, Ayata M, et al. (2002). "Susceptibility of human dendritic cells (DCs) to measles virus (MV) depends on their activation stages in conjunction with the level of CDw150: role of Toll stimulators in DC maturation and MV amplification.". Microbes Infect. 4 (8): 785–94. doi:10.1016/S1286-4579(02)01598-8. PMID 12270725.
- Li C, Iosef C, Jia CY, et al. (2003). "Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors.". J. Biol. Chem. 278 (6): 3852–9. doi:10.1074/jbc.M206649200. PMID 12458214.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Hahm B, Arbour N, Naniche D, et al. (2003). "Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule.". J. Virol. 77 (6): 3505–15. doi:10.1128/JVI.77.6.3505-3515.2003. PMC 149525. PMID 12610126. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149525.
- Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2).". J. Biol. Chem. 278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID 12621057.
- Ferrand V, Li C, Romeo G, Yin L (2003). "Absence of SLAM mutations in EBV-associated lymphoproliferative disease patients.". J. Med. Virol. 70 (1): 131–6. doi:10.1002/jmv.10373. PMID 12629654.
- Laaksonen K, Junikka M, Lahesmaa R, et al. (2004). "In vitro allergen-induced mRNA expression of signaling lymphocytic activation molecule by PBMC of patients with allergic rhinitis is increased during specific pollen immunotherapy.". J. Allergy Clin. Immunol. 112 (6): 1171–7. doi:10.1016/j.jaci.2003.08.043. PMID 14657878.
 |
This membrane protein-related article is a stub. You can help Wikipedia by expanding it. |
