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Signaling lymphocytic activation molecule family member 1
PDB 1d4t EBI.jpg
Rendering of SLAMF1 from PDB 1D4T
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SLAMF1 ; CD150; CDw150; SLAM
External IDs OMIM603492 MGI1351314 HomoloGene48162 GeneCards: SLAMF1 Gene
RNA expression pattern
PBB GE SLAMF1 206181 at tn.png
More reference expression data
Species Human Mouse
Entrez 6504 27218
Ensembl ENSG00000117090 ENSMUSG00000015316
UniProt Q13291 Q9QUM4
RefSeq (mRNA) NM_003037 NM_013730
RefSeq (protein) NP_003028 NP_038758
Location (UCSC) Chr 1:
160.58 – 160.62 Mb
Chr 1:
171.77 – 171.8 Mb
PubMed search [1] [2]

Signaling lymphocytic activation molecule is a protein that in humans is encoded by the SLAMF1 gene.[1][2]

SLAMF1 has also recently has been designated CD150 (cluster of differentiation 150).


SLAMF1 has been shown to interact with PTPN11,[3][4] SH2D1A[3][5] and SH2D1B.[4]


  1. ^ Cocks BG, Chang CC, Carballido JM, Yssel H, de Vries JE, Aversa G (August 1995). "A novel receptor involved in T-cell activation". Nature 376 (6537): 260–3. doi:10.1038/376260a0. PMID 7617038. 
  2. ^ "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1". 
  3. ^ a b Howie, Duncan; Simarro María; Sayos Joan; Guirado Maria; Sancho Jaime; Terhorst Cox (February 2002). "Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation". Blood (United States) 99 (3): 957–65. doi:10.1182/blood.V99.3.957. ISSN 0006-4971. PMID 11806999. 
  4. ^ a b Morra, M; Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle A J, Denny C, Yaffe M B, Engel P, Eck M J, Terhorst C (November 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. (England) 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. ISSN 0261-4189. PMC 125701. PMID 11689425. 
  5. ^ Morra, M; Simarro-Grande M, Martin M, Chen A S, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck M J, Sumegi J, Engel P, Li S C, Terhorst C (September 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients". J. Biol. Chem. (United States) 276 (39): 36809–16. doi:10.1074/jbc.M101305200. ISSN 0021-9258. PMID 11477068. 

Further reading[edit]