The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.
Claus M, Meinke S, Bhat R, Watzl C (2007). "Regulation of NK cell activity by 2B4, NTB-A and CRACC.". Front. Biosci.13 (13): 956–65. doi:10.2741/2735. PMID17981603.
Hercend T, Meuer S, Brennan A, et al. (1984). "Natural killer-like function of activated T lymphocytes: differential blocking effects of monoclonal antibodies specific for a 90-kDa clonotypic structure". Cell. Immunol.86 (2): 381–92. doi:10.1016/0008-8749(84)90393-9. PMID6610481.
Lee YJ, Luisiri P, Clark MR (1996). "A novel complex, p40/42, is constitutively associated with the B cell antigen receptor and phosphorylated upon receptor stimulation". J. Immunol.157 (9): 3828–37. PMID8892612.
Gray CW, Ward RV, Karran E, et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem.267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID10971580.
Del Valle JM, Engel P, Martín M (2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2)". J. Biol. Chem.278 (19): 17430–7. doi:10.1074/jbc.M301569200. PMID12621057.
Tangye SG, Nichols KE, Hare NJ, van de Weerdt BC (2003). "Functional requirements for interactions between CD84 and Src homology 2 domain-containing proteins and their contribution to human T cell activation". J. Immunol.171 (5): 2485–95. doi:10.4049/jimmunol.171.5.2485. PMID12928397.
Valdez PA, Wang H, Seshasayee D, et al. (2004). "NTB-A, a new activating receptor in T cells that regulates autoimmune disease". J. Biol. Chem.279 (18): 18662–9. doi:10.1074/jbc.M312313200. PMID14988414.
Cao E, Ramagopal UA, Fedorov A, et al. (2006). "NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family". Immunity25 (4): 559–70. doi:10.1016/j.immuni.2006.06.020. PMID17045824.