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SLAM family member 6
Protein SLAMF6 PDB 2if7.png
PDB rendering based on 2if7.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SLAMF6 ; CD352; KALI; KALIb; Ly108; NTB-A; NTBA; SF2000
External IDs OMIM606446 MGI1353620 HomoloGene49945 GeneCards: SLAMF6 Gene
Species Human Mouse
Entrez 114836 30925
Ensembl ENSG00000162739 ENSMUSG00000015314
UniProt Q96DU3 Q9ET39
RefSeq (mRNA) NM_001184714 NM_030710
RefSeq (protein) NP_001171643 NP_109635
Location (UCSC) Chr 1:
160.45 – 160.49 Mb
Chr 1:
171.92 – 171.94 Mb
PubMed search [1] [2]

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.[1][2]

The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.[2]


Further reading[edit]