SLC10A1

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Solute carrier family 10 (sodium/bile acid cotransporter family), member 1
Identifiers
Symbols SLC10A1 ; NTCP
External IDs OMIM182396 MGI97379 HomoloGene31126 ChEMBL: 5287 GeneCards: SLC10A1 Gene
RNA expression pattern
PBB GE SLC10A1 207185 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6554 20493
Ensembl ENSG00000100652 ENSMUSG00000021135
UniProt Q14973 O08705
RefSeq (mRNA) NM_003049 NM_001177561
RefSeq (protein) NP_003040 NP_001171032
Location (UCSC) Chr 14:
70.24 – 70.26 Mb
Chr 12:
80.95 – 80.97 Mb
PubMed search [1] [2]

Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.[1][2]

Function[edit]

Sodium/bile acid cotransporters are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids, one absorbing from the intestinal lumen, the bile duct, and the kidney with an apical localization (SLC10A2), and the other being found in the basolateral membranes of hepatocytes (SLC10A1; this protein).[1]

NTCP is a cell surface receptor necessary for the entry of Hepatitis B and Hepatitis D Virus.[3]

See also[edit]

References[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.