Monocarboxylate transporter 1

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Solute carrier family 16 (monocarboxylate transporter), member 1
Identifiers
Symbols SLC16A1 ; HHF7; MCT; MCT1
External IDs OMIM600682 MGI106013 HomoloGene20662 IUPHAR: 988 ChEMBL: 4360 GeneCards: SLC16A1 Gene
RNA expression pattern
PBB GE SLC16A1 202236 s at tn.png
PBB GE SLC16A1 202234 s at tn.png
PBB GE SLC16A1 202235 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6566 20501
Ensembl ENSG00000155380 ENSMUSG00000032902
UniProt P53985 P53986
RefSeq (mRNA) NM_001166496 NM_009196
RefSeq (protein) NP_001159968 NP_033222
Location (UCSC) Chr 1:
113.45 – 113.5 Mb
Chr 3:
104.64 – 104.66 Mb
PubMed search [1] [2]

Monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC16A1 gene (also known as MCT1).[1][2][3] It is a proton coupled monocarboxylate transporter.

Detailed kinetic analysis of monocarboxylate transport in erythrocytes revealed that MCT1 operates through an ordered mechanism. MCT1 has a substrate binding site open to the extracellular matrix which binds a proton first followed by the lactate anion. The protein then undergoes a conformational change to a new ‘closed’’ conformation that exposes both the proton and lactate to the opposite surface of the membrane where they are released, lactate first and then the proton. For net transport of lactic acid, the rate-limiting step is the return of MCT1 without bound substrate to the open conformation. For this reason, exchange of one monocarboxylate inside the cell with another outside is considerably faster than net transport of a monocarboxylate across the membrane.

See also[edit]

References[edit]

  1. ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722. 
  2. ^ Garcia CK, Li X, Luna J, Francke U (Sep 1994). "cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12". Genomics 23 (2): 500–3. doi:10.1006/geno.1994.1532. PMID 7835905. 
  3. ^ "Entrez Gene: SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1)". 

Further reading[edit]