SLC19A1

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Solute carrier family 19 (folate transporter), member 1
Identifiers
Symbols SLC19A1 ; CHMD; FOLT; IFC1; REFC; RFC1
External IDs OMIM600424 MGI103182 HomoloGene57139 ChEMBL: 4833 GeneCards: SLC19A1 Gene
RNA expression pattern
PBB GE SLC19A1 211576 s at tn.png
PBB GE SLC19A1 209775 x at tn.png
PBB GE SLC19A1 209776 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6573 20509
Ensembl ENSG00000173638 ENSMUSG00000001436
UniProt P41440 P41438
RefSeq (mRNA) NM_001205206 NM_001199271
RefSeq (protein) NP_001192135 NP_001186200
Location (UCSC) Chr 21:
46.91 – 46.96 Mb
Chr 10:
77.03 – 77.06 Mb
PubMed search [1] [2]

Solute carrier family 19 (folate transporter), member 1, also known as SLC19A1 or RFC1, is a protein which in humans is encoded by the SLC19A1 gene.[1]

Function[edit]

Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[2]

Clinical significance[edit]

Individuals carrying a specific polymorphism of SLC19A1 (c.80GG) have lower levels of folate.[3] Other studies have also shown that individuals carrying the c.80AA polymrophism who are treated with methotrexate have higher levels of this anti-folate chemotherapeutic agent. Personalized dosing of the drug depending on the patient's genotype may therefore be required.

See also[edit]

References[edit]

  1. ^ Lapenta V, Sossi V, Gosset P, Vayssettes C, Vitali T, Rabatel N, Tassone F, Blouin JL, Scott HS, Antonarakis SE, Créau N, Brahe C (April 1998). "Construction of a 2.5-Mb integrated physical and gene map of distal 21q22.3". Genomics 49 (1): 1–13. doi:10.1006/geno.1997.5185. PMID 9570943. 
  2. ^ "Entrez Gene: SLC19A1 solute carrier family 19 (folate transporter), member 1". 
  3. ^ Stanisławska-Sachadyn A, Mitchell LE, Woodside JV, Buckley PT, Kealey C, Young IS, Scott JM, Murray L, Boreham CA, McNulty H, Strain JJ, Whitehead AS (September 2009). "The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women". Ann. Hum. Genet. 73 (Pt 5): 484–491. doi:10.1111/j.1469-1809.2009.00529.x. PMC 2812009. PMID 19650776. Lay summaryPGxNews.Org. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.