SLC1A1

Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Identifiers
Symbols	SLC1A1; EAAC1; EAAT3
External IDs	OMIM: 133550 MGI: 105083 HomoloGene: 20881 GeneCards: SLC1A1 Gene
Gene Ontology Molecular function • L-glutamate transmembrane transporter activity • high-affinity glutamate transmembrane transporter activity • symporter activity • glutamate:sodium symporter activity • glutamate binding • sodium:dicarboxylate symporter activity Cellular component • membrane fraction • plasma membrane • integral to plasma membrane Biological process • ion transport • dicarboxylic acid transport • synaptic transmission • L-glutamate transport • protein homooligomerization • L-glutamate import • transmembrane transport • D-aspartate import Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6505	20510
Ensembl	ENSG00000106688	ENSMUSG00000024935
UniProt	P43005	Q6P1F7
RefSeq (mRNA)	NM_004170	NM_009199.2
RefSeq (protein)	NP_004161	NP_033225.1
Location (UCSC)	Chr 9: 4.49 – 4.59 Mb	Chr 19: 28.91 – 28.99 Mb
PubMed search	[1]	[2]

Excitatory amino-acid transporter 3 is a protein that in humans is encoded by the SLC1A1 gene.

Interactions

SLC1A1 has been shown to interact with ARL6IP5.

See also

• Glutamate transporter
• Solute carrier family

Further reading

• Nieoullon A, Canolle B, Masmejean F et al (2006). "The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?". J. Neurochem. 98 (4): 1007–18. doi:10.1111/j.1471-4159.2006.03978.x. PMID 16800850. 
• Arriza JL, Fairman WA, Wadiche JI et al (1994). "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex". J. Neurosci. 14 (9): 5559–69. PMID 7521911. 
• Shashidharan P, Huntley GW, Meyer T et al (1995). "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain". Brain Res. 662 (1–2): 245–50. doi:10.1016/0006-8993(94)90819-2. PMID 7859077. 
• Kanai Y, Stelzner M, Nussberger S et al (1994). "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport". J. Biol. Chem. 269 (32): 20599–606. PMID 7914198. 
• Zerangue N, Kavanaugh MP (1997). "Interaction of L-cysteine with a human excitatory amino acid transporter". J. Physiol. (Lond.) 493 ( Pt 2) (Pt 2): 419–23. PMC 1158927. PMID 8782106. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1158927. 
• Bar-Peled O, Ben-Hur H, Biegon A et al (1997). "Distribution of glutamate transporter subtypes during human brain development". J. Neurochem. 69 (6): 2571–80. doi:10.1046/j.1471-4159.1997.69062571.x. PMID 9375691. 
• He Y, Janssen WG, Rothstein JD, Morrison JH (2000). "Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus". J. Comp. Neurol. 418 (3): 255–69. doi:10.1002/(SICI)1096-9861(20000313)418:3<255::AID-CNE2>3.0.CO;2-6. PMID 10701825. 
• Lin CI, Orlov I, Ruggiero AM et al (2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046. 
• Veenstra-VanderWeele J, Kim SJ, Gonen D et al (2001). "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder". Mol. Psychiatry 6 (2): 160–7. doi:10.1038/sj.mp.4000806. PMID 11317217. 
• Borre L, Kavanaugh MP, Kanner BI (2002). "Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter". J. Biol. Chem. 277 (16): 13501–7. doi:10.1074/jbc.M110861200. PMID 11823462. 
• Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• González MI, Bannerman PG, Robinson MB (2003). "Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1". J. Neurosci. 23 (13): 5589–93. PMID 12843260. 
• Noorlander CW, de Graan PN, Nikkels PG et al (2004). "Distribution of glutamate transporters in the human placenta". Placenta 25 (6): 489–95. doi:10.1016/j.placenta.2003.10.018. PMID 15135231. 
• Humphray SJ, Oliver K, Hunt AR et al (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2734081. 
• Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Koch HP, Larsson HP (2005). "Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters". J. Neurosci. 25 (7): 1730–6. doi:10.1523/JNEUROSCI.4138-04.2005. PMID 15716409. 
• Vallejo-Illarramendi A, Domercq M, Pérez-Cerdá F et al (2006). "Increased expression and function of glutamate transporters in multiple sclerosis". Neurobiol. Dis. 21 (1): 154–64. doi:10.1016/j.nbd.2005.06.017. PMID 16061389. 
• Rual JF, Venkatesan K, Hao T et al (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Rainesalo S, Keränen T, Saransaari P, Honkaniemi J (2006). "GABA and glutamate transporters are expressed in human platelets". Brain Res. Mol. Brain Res. 141 (2): 161–5. doi:10.1016/j.molbrainres.2005.08.013. PMID 16198020. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.