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Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Symbols SLC1A1 ; EAAC1; EAAT3; SCZD18
External IDs OMIM133550 MGI105083 HomoloGene20881 ChEMBL: 2721 GeneCards: SLC1A1 Gene
RNA expression pattern
PBB GE SLC1A1 213664 at tn.png
PBB GE SLC1A1 206396 at tn.png
More reference expression data
Species Human Mouse
Entrez 6505 20510
Ensembl ENSG00000106688 ENSMUSG00000024935
UniProt P43005 P51906
RefSeq (mRNA) NM_004170 NM_009199
RefSeq (protein) NP_004161 NP_033225
Location (UCSC) Chr 9:
4.49 – 4.59 Mb
Chr 19:
28.84 – 28.91 Mb
PubMed search [1] [2]

Excitatory amino-acid transporter 3 (EAAT3) also known as the high affinity glutamate transporter is a protein that in humans is encoded by the SLC1A1 gene.[1][2]


The Excitatory amino-acid transporter 3 member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect.[2]


SLC1A1 has been shown to interact with ARL6IP5.[3]

See also[edit]


  1. ^ Smith CP, Weremowicz S, Kanai Y, Stelzner M, Morton CC, Hediger MA (August 1994). "Assignment of the gene coding for the human high-affinity glutamate transporter EAAC1 to 9p24: potential role in dicarboxylic aminoaciduria and neurodegenerative disorders". Genomics 20 (2): 335–6. doi:10.1006/geno.1994.1183. PMID 8020993. 
  2. ^ a b "Entrez Gene: SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1". 
  3. ^ Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M et al. (2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046. 

Further reading[edit]

  • Nieoullon A, Canolle B, Masmejean F, Guillet B, Pisano P, Lortet S (2006). "The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?". J. Neurochem. 98 (4): 1007–18. doi:10.1111/j.1471-4159.2006.03978.x. PMID 16800850. 
  • Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG (1994). "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex". J. Neurosci. 14 (9): 5559–69. PMID 7521911. 
  • Shashidharan P, Huntley GW, Meyer T, Morrison JH, Plaitakis A (1994). "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain". Brain Res. 662 (1-2): 245–50. doi:10.1016/0006-8993(94)90819-2. PMID 7859077. 
  • Kanai Y, Stelzner M, Nussberger S, Khawaja S, Hebert SC, Smith CP et al. (1994). "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport". J. Biol. Chem. 269 (32): 20599–606. PMID 7914198. 
  • Zerangue N, Kavanaugh MP (1996). "Interaction of L-cysteine with a human excitatory amino acid transporter". J. Physiol. (Lond.). 493 ( Pt 2) (Pt 2): 419–23. PMC 1158927. PMID 8782106. 
  • Bar-Peled O, Ben-Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A et al. (1997). "Distribution of glutamate transporter subtypes during human brain development". J. Neurochem. 69 (6): 2571–80. doi:10.1046/j.1471-4159.1997.69062571.x. PMID 9375691. 
  • He Y, Janssen WG, Rothstein JD, Morrison JH (2000). "Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus". J. Comp. Neurol. 418 (3): 255–69. doi:10.1002/(SICI)1096-9861(20000313)418:3<255::AID-CNE2>3.0.CO;2-6. PMID 10701825. 
  • Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M et al. (2001). "Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18". Nature 410 (6824): 84–8. doi:10.1038/35065084. PMID 11242046. 
  • Veenstra-VanderWeele J, Kim SJ, Gonen D, Hanna GL, Leventhal BL, Cook EH (2001). "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder". Mol. Psychiatry 6 (2): 160–7. doi:10.1038/ PMID 11317217. 
  • Borre L, Kavanaugh MP, Kanner BI (2002). "Dynamic equilibrium between coupled and uncoupled modes of a neuronal glutamate transporter". J. Biol. Chem. 277 (16): 13501–7. doi:10.1074/jbc.M110861200. PMID 11823462. 
  • González MI, Bannerman PG, Robinson MB (2003). "Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1". J. Neurosci. 23 (13): 5589–93. PMID 12843260. 
  • Noorlander CW, de Graan PN, Nikkels PG, Schrama LH, Visser GH (2004). "Distribution of glutamate transporters in the human placenta". Placenta 25 (6): 489–95. doi:10.1016/j.placenta.2003.10.018. PMID 15135231. 
  • Koch HP, Larsson HP (2005). "Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters". J. Neurosci. 25 (7): 1730–6. doi:10.1523/JNEUROSCI.4138-04.2005. PMID 15716409. 
  • Vallejo-Illarramendi A, Domercq M, Pérez-Cerdá F, Ravid R, Matute C (2006). "Increased expression and function of glutamate transporters in multiple sclerosis". Neurobiol. Dis. 21 (1): 154–64. doi:10.1016/j.nbd.2005.06.017. PMID 16061389. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Rainesalo S, Keränen T, Saransaari P, Honkaniemi J (2005). "GABA and glutamate transporters are expressed in human platelets". Brain Res. Mol. Brain Res. 141 (2): 161–5. doi:10.1016/j.molbrainres.2005.08.013. PMID 16198020. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.