SLC22A18

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Solute carrier family 22, member 18
Identifiers
Symbols SLC22A18 ; BWR1A; BWSCR1A; HET; IMPT1; ITM; ORCTL2; SLC22A1L; TSSC5; p45-BWR1A
External IDs OMIM602631 MGI1336884 HomoloGene1918 GeneCards: SLC22A18 Gene
RNA expression pattern
PBB GE SLC22A18 204981 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5002 18400
Ensembl ENSG00000110628 ENSMUSG00000000154
UniProt Q96BI1 Q78KK3
RefSeq (mRNA) NM_002555 NM_001042760
RefSeq (protein) NP_002546 NP_001036225
Location (UCSC) Chr 11:
2.92 – 2.95 Mb
Chr 7:
143.47 – 143.5 Mb
PubMed search [1] [2]

Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.[1][2][3]

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.[3]

See also[edit]

References[edit]

  1. ^ Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B (May 1998). "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Hum Mol Genet 7 (4): 597–608. doi:10.1093/hmg/7.4.597. PMID 9499412. 
  2. ^ Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M (May 1998). "Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples". Proc Natl Acad Sci U S A 95 (7): 3873–8. doi:10.1073/pnas.95.7.3873. PMC 19930. PMID 9520460. 
  3. ^ a b "Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.