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Solute carrier family 22, member 18
Symbols SLC22A18 ; BWR1A; BWSCR1A; HET; IMPT1; ITM; ORCTL2; SLC22A1L; TSSC5; p45-BWR1A
External IDs OMIM602631 MGI1336884 HomoloGene1918 IUPHAR: 1036 GeneCards: SLC22A18 Gene
RNA expression pattern
PBB GE SLC22A18 204981 at tn.png
More reference expression data
Species Human Mouse
Entrez 5002 18400
Ensembl ENSG00000110628 ENSMUSG00000000154
UniProt Q96BI1 Q78KK3
RefSeq (mRNA) NM_002555 NM_001042760
RefSeq (protein) NP_002546 NP_001036225
Location (UCSC) Chr 11:
2.92 – 2.95 Mb
Chr 7:
143.47 – 143.5 Mb
PubMed search [1] [2]

Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.[1][2][3]

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.[3]

See also[edit]


  1. ^ Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B (May 1998). "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Hum Mol Genet 7 (4): 597–608. doi:10.1093/hmg/7.4.597. PMID 9499412. 
  2. ^ Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M (May 1998). "Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples". Proc Natl Acad Sci U S A 95 (7): 3873–8. doi:10.1073/pnas.95.7.3873. PMC 19930. PMID 9520460. 
  3. ^ a b "Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.