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Solute carrier family 25, member 27
Symbols SLC25A27 ; UCP4
External IDs OMIM613725 MGI1921261 HomoloGene12523 IUPHAR: 1069 GeneCards: SLC25A27 Gene
Species Human Mouse
Entrez 9481 74011
Ensembl ENSG00000153291 ENSMUSG00000023912
UniProt O95847 E9Q874
RefSeq (mRNA) NM_001204051 NM_028711
RefSeq (protein) NP_001190980 NP_082987
Location (UCSC) Chr 6:
46.62 – 46.65 Mb
Chr 17:
43.64 – 43.67 Mb
PubMed search [1] [2]

Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene.[1][2][3]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are detected only in brain tissue and are specifically modulated by various environmental conditions.[3] Recently, the proton transport activity of UCP4 has also been shown to be activated by fatty acids and inhibited by purine nucleotides. [4] In addition, reconstituted UCP4 exhibited a distinct conformation, compared to other UCPs in the family.[5]

See also[edit]


  1. ^ Mao W, Yu XX, Zhong A, Li W, Brush J, Sherwood SW, Adams SH, Pan G (Mar 1999). "UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells". FEBS Lett 443 (3): 326–30. doi:10.1016/S0014-5793(98)01713-X. PMID 10025957. 
  2. ^ Jezek P, Urbankova E (Jun 2000). "Specific sequence of motifs of mitochondrial uncoupling proteins". IUBMB Life 49 (1): 63–70. doi:10.1080/713803586. PMID 10772343. 
  3. ^ a b "Entrez Gene: SLC25A27 solute carrier family 25, member 27". 
  4. ^ Hoang T, Smith MD, Jelokhani-Niaraki M (2012). "Toward Understanding the Mechanism of Ion Transport Activity of Neuronal Uncoupling Proteins UCP2, UCP4, and UCP5". Biochemistry 51 (19): 4004–14. doi:10.1021/bi3003378. PMID 22524567. 
  5. ^ Ivanova M, Hoang T, McSorly FR, Krnac G, Smith MD, Jelokhani-Niaraki M (2010). "A comparative study on conformation and ligand binding of the neuronal uncoupling proteins". Biochemistry 49 (3): 512–21. doi:10.1021/bi901742g. PMID 20000716. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.