SLC25A29

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Solute carrier family 25, member 29 is a protein that in humans is encoded by the SLC25A29 gene.[1] The gene is also known as CACL and C14orf69.[1] SLC25A29 belongs to a protein family of solute carriers called the mitochondrial carriers.[1]

Model organisms[edit]

Model organisms have been used in the study of SLC25A29 function. A conditional knockout mouse line, called Slc25a29tm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty four tests were carried out on mutant mice, but no significant abnormalities were observed.[4]

References[edit]

  1. ^ a b c "Solute carrier family 25, member 29". Retrieved 2011-12-05. 
  2. ^ "Salmonella infection data for Slc25a29". Wellcome Trust Sanger Institute. 
  3. ^ "Citrobacter infection data for Slc25a29". Wellcome Trust Sanger Institute. 
  4. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  5. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ^ "International Knockout Mouse Consortium". 
  7. ^ "Mouse Genome Informatics". 
  8. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.  edit
  9. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  10. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  11. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 

Further reading[edit]

  • Camacho, J. E. A.; Rioseco-Camacho, N. (2009). "The Human and Mouse SLC25A29 Mitochondrial Transporters Rescue the Deficient Ornithine Metabolism in Fibroblasts of Patients with the Hyperornithinemia-Hyperammonemia-Homocitrullinuria (HHH) Syndrome". Pediatric Research 66 (1): 35–41. doi:10.1203/PDR.0b013e3181a283c1. PMID 19287344.  edit
  • Sekoguchi, E.; Sato, N.; Yasui, A.; Fukada, S.; Nimura, Y.; Aburatani, H.; Ikeda, K.; Matsuura, A. (2003). "A Novel Mitochondrial Carnitine-acylcarnitine Translocase Induced by Partial Hepatectomy and Fasting". Journal of Biological Chemistry 278 (40): 38796–38802. doi:10.1074/jbc.M306372200. PMID 12882971.  edit