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Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
Symbols SLC25A3 ; PHC; PTP
External IDs OMIM600370 MGI1353498 HomoloGene37649 IUPHAR: 1061 GeneCards: SLC25A3 Gene
Species Human Mouse
Entrez 5250 18674
Ensembl ENSG00000075415 ENSMUSG00000061904
UniProt Q00325 Q8VEM8
RefSeq (mRNA) NM_002635 NM_133668
RefSeq (protein) NP_002626 NP_598429
Location (UCSC) Chr 12:
98.99 – 99 Mb
Chr 10:
91.12 – 91.12 Mb
PubMed search [1] [2]

Phosphate carrier protein, mitochondrial is a protein that in humans is encoded by the SLC25A3 gene.[1][2]

The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated.[2]

See also[edit]


  1. ^ Jabs EW, Thomas PJ, Bernstein M, Coss C, Ferreira GC, Pedersen PL (Jun 1994). "Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier". Hum Genet 93 (5): 600–2. doi:10.1007/bf00202832. PMID 8168843. 
  2. ^ a b "Entrez Gene: SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.