SLC25A4

Solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
PDB rendering based on 1okc.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1okc, 2c3e
Identifiers
Symbols	SLC25A4; AAC1; ANT; ANT1; PEO2; PEO3; T1
External IDs	OMIM: 103220 MGI: 1353495 HomoloGene: 36058 GeneCards: SLC25A4 Gene
Gene Ontology Molecular function • transporter activity • ATP:ADP antiporter activity • protein binding • adenine transmembrane transporter activity • enzyme binding Cellular component • mitochondrion • mitochondrial outer membrane • mitochondrial inner membrane • integral to plasma membrane • membrane Biological process • mitochondrial genome maintenance • generation of precursor metabolites and energy • energy reserve metabolic process • transport • apoptotic mitochondrial changes • adenine transport • ADP transport • ATP transport • viral reproduction • small molecule metabolic process • interspecies interaction between organisms • regulation of insulin secretion • glutamate uptake involved in synaptic transmission • transmembrane transport • negative regulation of necrotic cell death Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	291	11739
Ensembl	ENSG00000151729	ENSMUSG00000031633
UniProt	P12235	P48962
RefSeq (mRNA)	NM_001151.3	NM_007450.4
RefSeq (protein)	NP_001142.2	NP_031476.3
Location (UCSC)	Chr 4: 186.06 – 186.07 Mb	Chr 8: 47.29 – 47.3 Mb
PubMed search	[1]	[2]

ADP/ATP translocase 1 is an enzyme that in humans is encoded by the SLC25A4 gene or adenine nucleotide translocator, ANT.

Interactions

SLC25A4 has been shown to interact with Bcl-2-associated X protein.

Further reading

• Vieira HL, Haouzi D, El Hamel C, et al. (2001). "Permeabilization of the mitochondrial inner membrane during apoptosis: impact of the adenine nucleotide translocator.". Cell Death Differ. 7 (12): 1146–54. doi:10.1038/sj.cdd.4400778. PMID 11175251. 
• Ferri KF, Jacotot E, Blanco J, et al. (2001). "Mitochondrial control of cell death induced by HIV-1-encoded proteins.". Ann. N. Y. Acad. Sci. 926: 149–64. doi:10.1111/j.1749-6632.2000.tb05609.x. PMID 11193032. 
• Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377. 
• Andersen JL, Planelles V (2005). "The role of Vpr in HIV-1 pathogenesis.". Curr. HIV Res. 3 (1): 43–51. doi:10.2174/1570162052772988. PMID 15638722. 
• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=554975. 
• Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944. 
• Muthumani K, Choo AY, Premkumar A, et al. (2006). "Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism". Cell Death Differ. 12 Suppl 1: 962–70. doi:10.1038/sj.cdd.4401583. PMID 15832179. 
• Li L, Li HS, Pauza CD, et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571. 
• Moon HS, Yang JS (2006). "Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells". Mol. Cells 21 (1): 7–20. PMID 16511342. 
• Cozens AL, Runswick MJ, Walker JE (1989). "DNA sequences of two expressed nuclear genes for human mitochondrial ADP/ATP translocase". J. Mol. Biol. 206 (2): 261–80. doi:10.1016/0022-2836(89)90477-4. PMID 2541251. 
• Li K, Warner CK, Hodge JA, et al. (1989). "A human muscle adenine nucleotide translocator gene has four exons, is located on chromosome 4, and is differentially expressed". J. Biol. Chem. 264 (24): 13998–4004. PMID 2547778. 
• Neckelmann N, Li K, Wade RP, et al. (1987). "cDNA sequence of a human skeletal muscle ADP/ATP translocator: lack of a leader peptide, divergence from a fibroblast translocator cDNA, and coevolution with mitochondrial DNA genes". Proc. Natl. Acad. Sci. U.S.A. 84 (21): 7580–4. doi:10.1073/pnas.84.21.7580. PMC 299343. PMID 2823266. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=299343. 
• Houldsworth J, Attardi G (1988). "Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver". Proc. Natl. Acad. Sci. U.S.A. 85 (2): 377–81. doi:10.1073/pnas.85.2.377. PMC 279551. PMID 2829183. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=279551. 
• Wijmenga C, Winokur ST, Padberg GW, et al. (1993). "The human skeletal muscle adenine nucleotide translocator gene maps to chromosome 4q35 in the region of the facioscapulohumeral muscular dystrophy locus". Hum. Genet. 92 (2): 198–203. doi:10.1007/BF00219692. PMID 8103757. 
• Bakker HD, Scholte HR, Van den Bogert C, et al. (1993). "Deficiency of the adenine nucleotide translocator in muscle of a patient with myopathy and lactic acidosis: a new mitochondrial defect". Pediatr. Res. 33 (4 Pt 1): 412–7. PMID 8479824. 
• Kaukonen JA, Amati P, Suomalainen A, et al. (1996). "An autosomal locus predisposing to multiple deletions of mtDNA on chromosome 3p". Am. J. Hum. Genet. 58 (4): 763–9. PMC 1914672. PMID 8644740. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1914672. 
• Marzo I, Brenner C, Zamzami N, et al. (1998). "Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis". Science 281 (5385): 2027–31. doi:10.1126/science.281.5385.2027. PMID 9748162. 
• Kaukonen J, Zeviani M, Comi GP, et al. (1999). "A third locus predisposing to multiple deletions of mtDNA in autosomal dominant progressive external ophthalmoplegia". Am. J. Hum. Genet. 65 (1): 256–61. doi:10.1086/302445. PMC 1378100. PMID 10364542. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1378100. 
• Jacotot E, Ravagnan L, Loeffler M, et al. (2000). "The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore". J. Exp. Med. 191 (1): 33–46. doi:10.1084/jem.191.1.33. PMC 2195797. PMID 10620603. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2195797. 

External links

• MeSH SLC25A4+protein,+human