SLC26A7

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Solute carrier family 26 (anion exchanger), member 7
Identifiers
Symbols SLC26A7 ; SUT2
External IDs OMIM608479 MGI2384791 HomoloGene13770 IUPHAR: 1102 GeneCards: SLC26A7 Gene
Orthologs
Species Human Mouse
Entrez 115111 208890
Ensembl ENSG00000147606 ENSMUSG00000040569
UniProt Q8TE54 Q8R2Z3
RefSeq (mRNA) NM_001282356 NM_145947
RefSeq (protein) NP_001269285 NP_666059
Location (UCSC) Chr 8:
92.22 – 92.41 Mb
Chr 4:
14.5 – 14.62 Mb
PubMed search [1] [2]

Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.[1][2][3][4]

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Splice variants that use both alternate transcription initiation and polyadenylation sites have been described for this gene.[4]

See also[edit]

References[edit]

  1. ^ Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J Biol Chem 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742. 
  2. ^ Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495. 
  3. ^ Xu J, Worrell RT, Li HC, Barone SL, Petrovic S, Amlal H, Soleimani M (Mar 2006). "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion". J Am Soc Nephrol 17 (4): 956–67. doi:10.1681/ASN.2005111174. PMID 16524946. 
  4. ^ a b "Entrez Gene: SLC26A7 solute carrier family 26, member 7". 

Further reading[edit]

  • Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. PMID 11581495. 
  • Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Petrovic S; Ju X; Barone S et al. (2003). "Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells". Am. J. Physiol. Gastrointest. Liver Physiol. 284 (6): G1093–103. doi:10.1152/ajpgi.00454.2002. PMID 12736153. 
  • Petrovic S; Barone S; Xu J et al. (2004). "SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct". Am. J. Physiol. Renal Physiol. 286 (1): F161–9. doi:10.1152/ajprenal.00219.2003. PMID 12965893. 
  • Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Barone S; Amlal H; Xu J et al. (2004). "Differential regulation of basolateral Cl-/HCO3- exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct". J. Am. Soc. Nephrol. 15 (8): 2002–11. doi:10.1097/01.ASN.0000135060.83250.07. PMID 15284286. 
  • Kujala M; Tienari J; Lohi H et al. (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron Exp. Nephrol. 101 (2): e50–8. doi:10.1159/000086345. PMID 15956810. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.