SLC26A8

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Solute carrier family 26 (anion exchanger), member 8
Identifiers
Symbols SLC26A8 ; SPGF3; TAT1
External IDs OMIM608480 MGI2385046 HomoloGene27095 IUPHAR: 1105 GeneCards: SLC26A8 Gene
Orthologs
Species Human Mouse
Entrez 116369 224661
Ensembl ENSG00000112053 ENSMUSG00000036196
UniProt Q96RN1 Q8R0C3
RefSeq (mRNA) NM_001193476 NM_001290320
RefSeq (protein) NP_001180405 NP_001277249
Location (UCSC) Chr 6:
35.91 – 35.99 Mb
Chr 17:
28.64 – 28.69 Mb
PubMed search [1] [2]

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.[1][2][3]

Function[edit]

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.[3]

Interactions[edit]

SLC26A8 has been shown to interact with RACGAP1.[4]

References[edit]

  1. ^ Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U et al. (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J. Biol. Chem. 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742. 
  2. ^ Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495. 
  3. ^ a b "Entrez Gene: SLC26A8 solute carrier family 26, member 8". 
  4. ^ Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (Jun 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976. 

Further reading[edit]

  • Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. PMID 11581495. 
  • Mäkelä S, Eklund R, Lähdetie J, Mikkola M, Hovatta O, Kere J (2005). "Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure". Mol. Hum. Reprod. 11 (2): 129–32. doi:10.1093/molehr/gah140. PMID 15579655. 
  • Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976. 
  • Mocellin R, Bühlmeyer K (1975). "Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension". Eur J Cardiol 3 (3): 205–11. PMID 1183472.