Concentrative nucleoside transporter 1

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Solute carrier family 28 (concentrative nucleoside transporter), member 1
Identifiers
Symbols SLC28A1 ; CNT1; HCNT1
External IDs OMIM606207 MGI3605073 HomoloGene37902 IUPHAR: 1114 ChEMBL: 5551 GeneCards: SLC28A1 Gene
Orthologs
Species Human Mouse
Entrez 9154 434203
Ensembl ENSG00000156222 ENSMUSG00000025726
UniProt O00337 E9PXX9
RefSeq (mRNA) NM_001287761 NM_001004184
RefSeq (protein) NP_001274690 NP_001004184
Location (UCSC) Chr 15:
85.43 – 85.52 Mb
Chr 7:
81.11 – 81.17 Mb
PubMed search [1] [2]

Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.[1][2]

See also[edit]

References[edit]

  1. ^ Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD (Apr 1997). "Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)". Am J Physiol 272 (2 Pt 1): C707–14. PMID 9124315. 
  2. ^ "Entrez Gene: SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1". 

Further reading[edit]

  • Ritzel MW, Ng AM, Yao SY et al. (2001). "Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib).". Mol. Membr. Biol. 18 (1): 65–72. doi:10.1080/09687680118530. PMID 11396613. 
  • Ritzel MW, Yao SY, Ng AM et al. (1999). "Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine.". Mol. Membr. Biol. 15 (4): 203–11. doi:10.3109/09687689709044322. PMID 10087507. 
  • Loewen SK, Ng AM, Yao SY et al. (1999). "Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.". J. Biol. Chem. 274 (35): 24475–84. doi:10.1074/jbc.274.35.24475. PMID 10455109. 
  • Mata JF, García-Manteiga JM, Lostao MP et al. (2001). "Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug.". Mol. Pharmacol. 59 (6): 1542–8. PMID 11353816. 
  • Lai Y, Bakken AH, Unadkat JD (2002). "Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies.". J. Biol. Chem. 277 (40): 37711–7. doi:10.1074/jbc.M204986200. PMID 12097333. 
  • Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction.". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627. 
  • Molina-Arcas M, Bellosillo B, Casado FJ et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia.". Blood 101 (6): 2328–34. doi:10.1182/blood-2002-07-2236. PMID 12411296. 
  • Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • García-Manteiga J, Molina-Arcas M, Casado FJ et al. (2004). "Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity.". Clin. Cancer Res. 9 (13): 5000–8. PMID 14581375. 
  • Loewen SK, Yao SY, Slugoski MD et al. (2004). "Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes.". Mol. Membr. Biol. 21 (1): 1–10. doi:10.1080/0968768031000140836. PMID 14668133. 
  • Gray JH, Mangravite LM, Owen RP et al. (2004). "Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations.". Mol. Pharmacol. 65 (3): 512–9. doi:10.1124/mol.65.3.512. PMID 14978229. 
  • Farré X, Guillén-Gómez E, Sánchez L et al. (2004). "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors.". Int. J. Cancer 112 (6): 959–66. doi:10.1002/ijc.20524. PMID 15386342. 
  • Lai Y, Lee EW, Ton CC et al. (2005). "Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively.". Am. J. Physiol., Cell Physiol. 288 (1): C39–45. doi:10.1152/ajpcell.00192.2004. PMID 15456697. 
  • Fernández-Veledo S, Jover R, Casado FJ et al. (2007). "Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells.". Biochem. Biophys. Res. Commun. 353 (2): 381–8. doi:10.1016/j.bbrc.2006.12.021. PMID 17187757. 
  • Slugoski MD, Loewen SK, Ng AM et al. (2007). "Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling.". Biochemistry 46 (6): 1684–93. doi:10.1021/bi061692s. PMID 17279631. 
  • Smith KM, Slugoski MD, Cass CE et al. (2007). "Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3.". Mol. Membr. Biol. 24 (1): 53–64. doi:10.1080/09687860600942534. PMID 17453413. 
  • Guallar JP, Cano-Soldado P, Aymerich I et al. (2007). "Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients.". Antivir. Ther. (Lond.) 12 (6): 853–63. PMID 17926640.